FITC标记的γ-分泌酶组件蛋白NCLN抗体
产品名称： FITC标记的γ-分泌酶组件蛋白NCLN抗体
英文名称： Anti-Nicalin/FITC
产品编号： HZ-11594R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-Nicalin/FITC Conjugated antibody
FITC标记的γ-分泌酶组件蛋白NCLN抗体
| 产品编号 | bs-11594R-FITC |
| 英文名称 | Anti-Nicalin/FITC |
| 中文名称 | FITC标记的γ-分泌酶组件蛋白NCLN抗体 |
| 别 名 | NCLN; NCLN_HUMAN; NET59; Nicalin; Nicalin homolog (zebrafish); Nicastrin like protein; Nicastrin-like protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 生长因子和激素 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nicalin (401-500aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype. Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Subunit: Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. Similarity: Belongs to the nicastrin family. Database links: Entrez Gene: 56926 Human Entrez Gene: 103425 Mouse Entrez Gene: 314648 Rat Omim: 609156 Human SwissProt: Q969V3 Human SwissProt: Q8VCM8 Mouse SwissProt: Q5XIA1 Rat Unigene: 657032 Human Unigene: 302791 Mouse Unigene: 4202 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Nicastrin(NCT)是高度糖基化的I型跨膜蛋白,是γ-分泌酶复合物的重要组件蛋白之一,广泛分布于人类或鼠的所有细胞类型。它不仅与γ-分泌酶的组装和成熟密切相关,其构象及表达变化对γ-分泌酶活性和阿尔茨海默病(Alzheimer's disease,AD)中β淀粉样蛋白(amyloid proteinβ,Aβ)的产生及降解也起重要调节作用 |
尼克西汀是阿尔茨海默相关的γ分泌酶复合物的组成部分。NIALILN是一种类似于Nestalin的蛋白，与γ分泌酶无关，而是与NOMO（节调节剂）相互作用。节是TGF-β信号转导因子，控制脊椎动物发育过程中胚胎细胞规划阶段的各种细胞命运决定。NIALIN／NOMO复合物在肠化过程中调节淋巴结信号传导因子。这种调节最常影响轴向中胚层的发育。结信号是黑色素瘤细胞侵袭和致瘤性的重要因素，这种信号的抑制可以促进黑色素瘤细胞向黑素细胞表型恢复。