FITC标记的N-乙酰转移酶8样蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的N-乙酰转移酶8样蛋白抗体
英文名称: Anti-NAT8L/FITC
抗体货号: HZ-11593R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/1 15:57:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
021-60345367
传真:
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陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-NAT8L/FITC Conjugated antibody

FITC标记的N-乙酰转移酶8样蛋白抗体

 

产品编号 bs-11593R-FITC
英文名称 Anti-NAT8L/FITC
中文名称 FITC标记的N-乙酰转移酶8样蛋白抗体
别    名 Camello-like protein 3; CML3; Hcml3; N acetyltransferase 8 like (GCN5 related, putative); N-acetylaspartate synthetase; N-acetyltransferase 8-like protein; NAA synthetase; NAT8 like; Nat8l; NAT8L_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  发育生物学  信号转导  细胞周期蛋白  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NAT8L (201-302aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia).

Function:
Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates meth***-induced inhibition of dopamine uptake. 

Subcellular Location:
Cytoplasm. Membrane; Single-pass membrane protein (Potential). Microsome membrane; Single-pass membrane protein (By similarity). Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. 

Tissue Specificity:
Expressed in brain. 

DISEASE:
Defects in NAT8L are the cause of N-acetylaspartate deficiency (NACED) [MIM:614063]. A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly.

Similarity:
Belongs to the camello family. 
Contains 1 N-acetyltransferase domain. 

Database links:
Entrez Gene: 339983 Human
Entrez Gene: 269642 Mouse
Omim: 610647 Human
SwissProt: Q8N9F0 Human
SwissProt: Q3UGX3 Mouse
Unigene: 318529 Human
Unigene: 274610 Mouse


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

该基因编码单程膜蛋白,其包含N-乙酰转移酶的GCN5或NAT超家族的保守序列,并且是N-酰基转移酶(NAT)超家族的成员。该蛋白是一种神经元特异性蛋白,是N-乙酰天门冬氨酸(NAA)生物合成酶,催化L-天冬氨酸和acetyl CoA合成NAA。NAA是神经系统特有的乙酰辅酶A的主要储存和转运形式。基因突变导致原发性NAA缺乏(亚乙酰基)。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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