FITC标记的低密度脂蛋白受体5样蛋白抗体
产品名称： FITC标记的低密度脂蛋白受体5样蛋白抗体
英文名称： Anti-LRP5L/FITC
产品编号： HZ-11590R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-LRP5L/FITC Conjugated antibody
FITC标记的低密度脂蛋白受体5样蛋白抗体
| 产品编号 | bs-11590R-FITC |
| 英文名称 | Anti-LRP5L/FITC |
| 中文名称 | FITC标记的低密度脂蛋白受体5样蛋白抗体 |
| 别 名 | Low-density lipoprotein receptor-related protein 5-like protein; LRP-5-like; LRP5L; GP330; LRP5L_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 细胞周期蛋白 转录调节因子 表观遗传学 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRP5L (101-200aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Members of the LDL receptor gene family, including LDLR (low density lipo-protein receptor), LRPs (low density lipoprotein related proteins), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Of the known family members, LRP5 is most closely related to LRP1. However, LRP5 has a unique organization of EGF and LDLR repeats compared to other LDLR family members and likely represents a new category in this family. LRP is expressed in rat tibia, specifically in areas of the bone that are involved in remodeling. LRP5 is a Wnt coreceptor that binds to Axin and regulates the canonical Wnt signaling pathway. LRP5 affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). LRP5L is a related protein that exists as two isoforms produced by alternative splicing. Similarity: Contains 5 LDL-receptor class B repeats. Database links: UniProtKB/Swiss-Prot: A4QPB2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
LDL受体基因家族的成员，包括LDLR（低密度脂蛋白受体）、LRPs（低密度脂蛋白相关蛋白）、Megalin（也被命名为GP330）、VLDLR（极低密度脂蛋白受体）和ApOE2，其特征在于富含半胱氨酸的A类重复序列E。皮脂腺生长因子（EGF）样重复序列，YWTD重复序列和O-连接糖域。在已知家族成员中，LRP5与LRP1最密切相关。然而，LRP5与其他LDLR家族成员相比具有独特的EGF和LDLR重复组织，并且可能代表该家族中的一个新类别。LRP在大鼠胫骨中表达，特别是在涉及重塑的骨区域中。LRP5是与轴突结合并调节经典Wnt信号通路的Wnt受体。LRP5在生长过程中影响骨量增加。LRP5基因突变导致常染色体隐性遗传性骨质疏松假瘤综合征（OPGPG）。LRP5L是作为选择性剪接产生的两种异构体存在的一种相关蛋白。