Rabbit Anti-RND2/Rho7/FITC Conjugated antibody
|别 名||ARHN; Rho 7; Rho family GTPase 2; Rho N; Rho related GTP-binding protein RhoN; Rho-related GTP-binding protein Rho7; Rho-related GTP-binding protein RhoN; Rho7; RhoN; Rnd 2; Rnd2; RND2_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||神经生物学 信号转导 G蛋白偶联受体 G蛋白信号|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||25kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human RND2 (1-80aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.
May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily.
Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5.
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side (Potential). Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome.
Highly expressed in testis.
Belongs to the small GTPase superfamily. Rho family.
Entrez Gene: 8153 Human
Entrez Gene: 11858 Mouse
Entrez Gene: 303553 Rat
Omim: 601555 Human
SwissProt: P52198 Human
SwissProt: Q9QYM5 Mouse
Unigene: 603111 Human
Unigene: 378883 Mouse
Unigene: 22162 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
鸟嘌呤核苷酸家族的Ras p21家族由于其在人类恶性肿瘤中的信号转导途径和突变频率的明显作用而被广泛研究。然而，现在很清楚，Ras蛋白（H-，K-和N-ras p21）是一个更大的超家族相关蛋白的成员。这个家族的六个成员，RAP 1A，RAP 1B，RAP 2，R-ras，Ra A和Ral B，与RAS表现出大约50%的氨基酸同源性。六种哺乳动物Rho蛋白（Rho A、B、C、G、7和8）与RAS的同源性约为30%，并在广泛的细胞类型中表达。Ras P21和Rho P21以及Ras超家族的其他成员都含有羧基末端CAAX序列（C、半胱氨酸、A、脂肪族氨基酸、X、任何氨基酸），在RAS的情况下，它们被证明是正确定位和功能的关键。