FITC标记的磷酸二酯酶7B抗体
产品名称： FITC标记的磷酸二酯酶7B抗体
英文名称： Anti-PDE7B/FITC
产品编号： HZ-11576R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PDE7B/FITC Conjugated antibody
FITC标记的磷酸二酯酶7B抗体
| 产品编号 | bs-11576R-FITC |
| 英文名称 | Anti-PDE7B/FITC |
| 中文名称 | FITC标记的磷酸二酯酶7B抗体 |
| 别 名 | PDE 7B; PDE7B protein; Phosphodiesterase 7B; Phosphodiesterase7B; RNPDE7B; Rolipram insensitive phosphodiesterase type 7; bA472E5.1; cAMP specific 3 5 cyclic phosphodiesterase 7B; cAMP specific 3'5' cyclic phosphodiesterase 7B; High affinity cAMP specific 3 5 cyclic phosphodiesterase; High affinity cAMP specific 3'5' cyclic phosphodiesterase; PDE7B_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PDE7B (281-360aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Phosphodiesterases (PDE, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP. Phosphodiesterase type 3 isoforms, PDE3A and 3B, are expressed primarily in cardiovascular tissue and adipose tissue, respectively. PDE3A, is found in myocardium and platelets and PDE3B is found in lymphocytes. The PDE7A1 (HCP1) isozyme and the PDE7A2 proteins, alternate splice products of PDE7A, are highly expressed in skeletal muscle. PDE7B is most highly expressed in pancreas. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation. Function: PDE7B is a cAMP specific phosphodiesterase. The cAMP-specific phosphodiesterase type-7 (PDE7) family is comprised of 2 genes (PDE7A and PDE7B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites. PDE7B has three splice variants (PDE7B1 = 446 amino acid; PDE7B2 =359 amino acids and PDE7B3 = 459 amino acids. Both PDE7B2 ad PDE7B3 posses unique N-terminal sequences. PDE7B is expressed in various tissues including skeletal muscle, heart, lung and testis. PDE7B may be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. Tissue Specificity: Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas. Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. Database links: UniProtKB/Swiss-Prot: Q9NP56.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
磷酸二酯酶（PDE，又称环核苷酸磷酸二酯酶）对水解第二信使环磷酸腺苷（cAMP）的细胞内水平是重要的，通过将cAMP水解成5'AMP。磷酸二酯酶-3异构体，PDE3A和3B，主要表达在心血管组织和脂肪组织。PDE3A存在于心肌和血小板中，PDE3B存在于淋巴细胞中。PDE7A1（HCP1）同工酶和PDE7A2蛋白是骨骼肌中高表达的PDE7A交叉剪接产物。PDE7B在胰腺中表达最为明显。PDE家族包含蛋白质，其在调节脂解、糖原分解、心肌收缩和平滑肌舒张方面起到组织特异性的作用。