FITC标记的磷酸二酯酶7抗体-抗体-抗体-生物在线
FITC标记的磷酸二酯酶7抗体

FITC标记的磷酸二酯酶7抗体

商家询价

产品名称: FITC标记的磷酸二酯酶7抗体

英文名称: Anti-PDE7A/FITC

产品编号: HZ-11575R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-PDE7A/FITC Conjugated antibody

FITC标记的磷酸二酯酶7抗体

 

产品编号 bs-11575R-FITC
英文名称 Anti-PDE7A/FITC
中文名称 FITC标记的磷酸二酯酶7抗体
别    名 HCP 1; HCP1; High affinity cAMP specific 3'5' cyclic phosphodiesterase 7A; High affinity cAMP-specific 3''; P2A; PDE 7; PDE 7A; PDE7; PDE71; PDE7A; PDE7A_HUMAN; Phosphodiesterase 7A; Phosphodiesterase isozyme 7; Phosphodiesterase7A; Rolipram insensitive phosphodiesterase type 7; TM 22; TM22; 5''-cyclic phosphodiesterase 7A.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  神经生物学  信号转导  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PDE7A (341-440aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Phosphodiesterases (PDE, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP. Phosphodiesterase type 3 isoforms, PDE3A and 3B, are expressed primarily in cardiovascular tissue and adipose tissue, respectively. PDE3A, is found in myocardium and platelets and PDE3B is found in lymphocytes. The PDE7A1 (HCP1) isozyme and the PDE7A2 proteins, alternate splice products of PDE7A, are highly expressed in skeletal muscle. PDE7B is most highly expressed in pancreas. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation.

Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Subunit:
Interacts with CBFA2T3.

Subcellular Location:
Cytoplasm

Tissue Specificity:
PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.

Similarity:
Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.

Database links:

Entrez Gene: 5150 Human

Omim: 171885 Human

SwissProt: Q13946 Human

Unigene: 527119 Human

Unigene: 728847 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

磷酸二酯酶(PDE,又称环核苷酸磷酸二酯酶)对水解第二信使环磷酸腺苷(cAMP)的细胞内水平是重要的,通过将cAMP水解成5'AMP。磷酸二酯酶-3异构体,PDE3A和3B,主要表达在心血管组织和脂肪组织。PDE3A存在于心肌和血小板中,PDE3B存在于淋巴细胞中。PDE7A1(HCP1)同工酶和PDE7A2蛋白是骨骼肌中高表达的PDE7A交叉剪接产物。PDE7B在胰腺中表达最为明显。PDE家族包含蛋白质,其在调节脂解、糖原分解、心肌收缩和平滑肌舒张方面起到组织特异性的作用。