FITC标记的神经特异性转录因子DPF1抗体上海沪震实业有限公司

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产品名称: FITC标记的神经特异性转录因子DPF1抗体
英文名称: Anti-Neuro D/FITC
抗体货号: HZ-11573R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/5 14:27:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Neuro D/FITC Conjugated antibody

FITC标记的神经特异性转录因子DPF1抗体

 

产品编号 bs-11573R-FITC
英文名称 Anti-Neuro D/FITC
中文名称 FITC标记的神经特异性转录因子DPF1抗体
别    名 NeuroD4; BAF45B; BRG1-associated factor 45B; D4; DPF1; DPF 1; DPF=1; DPF1_HUMAN; NEUD4; NEUD 4; Zinc and double PHD fingers family 1; Zinc finger protein neuro-d4.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neuro D4 (301-380aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
DPF1 is a 353 amino acid protein that contains two PHD-type zinc fingers and belongs to the requiem/DPF family. Localized to both the nucleus and the cytoplasm, DPF1 is thought to play an important role in the regulation of neuronal cell survival. Specifically, DPF1 may function as a neurospecific transcription factor that binds DNA and participates in cell cycle progression. Human and rat DPF1 share 93% sequence identity, suggesting a conserved role between species. Multiple isoforms of DPF1 exist due to alternative splicing events.

Function:
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Subunit:
Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin

Subcellular Location:
Cytoplasm. Nucleus.

Similarity:
Belongs to the requiem/DPF family.
Contains 2 PHD-type zinc fingers.

Database links:

Entrez Gene: 8193 Human

Entrez Gene: 29861 Mouse

Entrez Gene: 50545 Rat

SwissProt: Q92782 Human

SwissProt: Q9QX66 Mouse

SwissProt: P56163 Rat

Unigene: 631576 Human

Unigene: 101885 Mouse

Unigene: 453136 Mouse

Unigene: 453137 Mouse

Unigene: 42906 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
   

 

DPF1是含有两个PHD型锌指的353氨基酸蛋白,属于安魂曲/DPF家族。定位于细胞核和细胞质中,DPF1被认为在调节神经元细胞存活中起重要作用。具体而言,DPF1可作为结合DNA并参与细胞周期进程的神经特异性转录因子。人和大鼠DPF1共有93%个序列同一性,提示物种间具有保守的作用。由于选择性剪接事件,存在DPF1的多个异构体

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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