FITC标记的富含亮氨酸重复跨膜神经元蛋白3抗体
产品名称： FITC标记的富含亮氨酸重复跨膜神经元蛋白3抗体
英文名称： Anti-LRRTM3/FITC
产品编号： HZ-11571R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LRRTM3/FITC Conjugated antibody
FITC标记的富含亮氨酸重复跨膜神经元蛋白3抗体
| 产品编号 | bs-11571R-FITC |
| 英文名称 | Anti-LRRTM3/FITC |
| 中文名称 | FITC标记的富含亮氨酸重复跨膜神经元蛋白3抗体 |
| 别 名 | Leucine rich repeat transmembrane neuronal protein 3; Leucine-rich repeat transmembrane neuronal protein 3; LRRT3_HUMAN; Lrrtm3; MGC131810; PRO1693; UNQ803. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep, Monkey, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRRTM3 (31-120aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM3 (leucine rich repeat transmembrane neuronal 3) is a 581 amino acid single-pass type I membrane protein belonging to the LRRTM family. LRRTM3 is involved in the development and maintenance of the vertebrate nervous system, and contains ten LRR repeats. Expressed in neuronal tissues, LRRTM3 is encoded by a gene that maps to a region of chromosome 10 that has been linked to late-onset Alzheimer disease and elevated plasma Beta-Amyloid. As a result of alternative splicing events, two LRRTM3 isoforms exist. Function: May play a role in the development and maintenance of the vertebrate nervous system. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein Tissue Specificity: Expressed in neuronal tissues. Similarity: Belongs to the LRRTM family. Contains 10 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Database links: Entrez Gene: 347731 Human Entrez Gene: 216028 Mouse Entrez Gene: 294380 Rat Omim: 610869 Human SwissProt: Q86VH5 Human SwissProt: Q8BZ81 Mouse Unigene: 652155 Human Unigene: 431318 Mouse Unigene: 214114 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
富含亮氨酸（LRR）的重复序列是20-30个氨基酸基序，形成疏水性α/β马蹄褶，允许其在紧密堆积的核心内容纳多个亮氨酸残基。所有的LRR重复包含可变片段和高度保守的片段，后者占整个LRR基序的11或12个残基。LRRTM蛋白家族在神经系统发育过程中对各种细胞事件的调节起作用。主要定位于神经系统，已知LRRTM家族成员具有突触发生活性。LRRTM3（富含亮氨酸重复的跨膜神经元3）是属于LRRTM家族的581氨基酸单程I型膜蛋白。LRRTM3参与脊椎动物神经系统的发育和维持，并包含十个LRR重复。在神经组织中表达，LRRTM3由一个基因编码，该基因映射到10号染色体的区域，该基因与迟发性阿尔茨海默病和血浆β淀粉样蛋白升高有关。作为选择性剪接事件的结果，存在两个LrRTM3亚型。