FITC标记的锌指蛋白Zdhhc12抗体
产品名称: FITC标记的锌指蛋白Zdhhc12抗体
英文名称: Anti-ZDHHC-12/FITC
产品编号: HZ-6958R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZDHHC-12/FITC Conjugated antibody
FITC标记的锌指蛋白Zdhhc12抗体
产品编号 | bs-6958R-FITC |
英文名称 | Anti-ZDHHC-12/FITC |
中文名称 | FITC标记的锌指蛋白Zdhhc12抗体 |
别 名 | DHHC12; DHHC-12; Palmitoyltransferase ZDHHC12; ZDH12_HUMAN; Zdhhc12; Zinc finger DHHC domain-containing protein 12; DHHC-12; Probable palmitoyltransferase ZDHHC12; ZDH12_HUMAN; ZDHHC12; Zinc finger DHHC domain-containing protein 12; Zinc finger DHHC type containing 12; Zinc finger protein 400; ZNF400. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 信号转导 转录调节因子 锌指蛋白 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 30kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human ZDHHC-12 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC12 (zinc finger, DHHC domain containing 12), also known as ZNF400, is a 267 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger and is thought to function as a palmitoyltransferase, catalyzing the transformation of palmitoyl-CoA and a cysteine-conjugated protein to a S-palmitoyl protein and free CoA. Three isoforms exist due to alternative splicing events. The gene encoding ZDHHC12 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Chromosome 9 is considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Subcellular Location: Membrane; Multi-pass membrane protein Similarity: Belongs to the DHHC palmitoyltransferase family. Contains 1 DHHC-type zinc finger. Database links: Entrez Gene: 505354 Cow Entrez Gene: 608478 Dog Entrez Gene: 100066906 Horse Entrez Gene: 84885 Human Entrez Gene: 100519816 Pig Entrez Gene: 366014 Rat SwissProt: Q96GR4 Human SwissProt: Q6DGF5 Rat Unigene: 133122 Human Unigene: 95138 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
锌指蛋白含有DNA结合结构域,具有广泛的功能,其中大部分包含某种形式的转录激活或抑制。ZDHHC12(锌指,含DHHC结构域12),也称为ZnF400,是一种含有267个氨基酸的多道膜蛋白,含有一个DHHC型锌指,被认为是棕榈酰基转移酶,催化棕榈酰辅酶A和半胱氨酸结合蛋白的转化。S-棕榈酰蛋白和游离辅酶A。三种异构体由于选择性剪接事件而存在。编码ZDHHC12的基因定位于人类染色体9,由约1亿4500万个碱基和4%个人类基因组组成,编码近900个基因。染色体9被认为在性别决定中起作用,9P末端缺失可导致男性与女性性别逆转的发展,女性具有男性X、Y基因型的表型。