FITC标记的ATP合成酶β5抗体上海沪震实业有限公司

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产品名称: FITC标记的ATP合成酶β5抗体
英文名称: Anti-ATP5B/FITC
抗体货号: HZ-8600R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/17 13:18:00
详细资料:  实验方法技术资料
浏览人数:6
诚信指数:1026点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-ATP5B/FITC Conjugated antibody

FITC标记的ATP合成酶β5抗体

 

产品编号 bs-8600R-FITC
英文名称 Anti-ATP5B/FITC
中文名称 FITC标记的ATP合成酶β5抗体
别    名 ATP 5B; ATP synthase H+ transporting mitochondrial F1 complex beta polypeptide; ATP Synthase H+ Transporting Mitochondrial F1 Complex Subunit Beta; ATP synthase subunit beta mitochondrial; ATP synthase subunit beta, mitochondrial; ATP5B; ATPB; ATPB_HUMAN; ATPMB; ATPSB; MGC5231; Mitochondrial ATP synthase beta subunit; Mitochondrial ATP Synthase Subunit Beta; Mitochondrial ATP synthetase beta subunit.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ATP5B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Mitochondrial ATP synthase is composed of two multi-subunit complexes that utilize an inner membrane electrochemical gradient to catalyze the synthesis of ATP during oxidative phosphorylation. The two multi-subunit complexes are designated F1 and F0, the former of which comprises the soluble catalytic core and the latter of which comprises the membrane-spanning proton channel of ATP synthase. F1 consists of five distinct subunits, designated ATP5A, ATP5B, ATP5C1, ATP5D and ATP5E, while F0 consists of ten subunits, designated ATP5H, ATP5G1, ATP5I, ATP5G2, ATP5J2, ATP5J, ATP5G3, ATP5S, ATP5F1 and ATP5L. ATP5B, also designated ATPMB, ATPSB or mitochondrial ATP synthetase, beta subunit, is a 529 amino acid protein that localizes to the mitochondrial membrane and exists as a subunit of the F0 complex. ATP5B is encoded by a nuclear gene and assembled with the other subunits encoded by both mitochondrial and nuclear genes. The ATP5B gene is activated by members of the Ets family of transcription factors, suggesting that Ets transcription factors are involved in the enhanced expression of the ATP5B gene in highly proliferating cells and in the coordinate transcription of nuclear genes for mitochondrial proteins. ATP5B mRNA levels vary among species through transcriptional control with high expression levels in heart, lower levels in skeletal muscle and the lowest levels in liver and kidney.

Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Subunit:
F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68

Subcellular Location:
Mitochondrion. Mitochondrion inner membrane. Peripheral membrane protein.

Similarity:
Belongs to the ATPase alpha/beta chains family.

Database links:

Entrez Gene: 327675 Cow

Entrez Gene: 506 Human

Entrez Gene: 11947 Mouse

Entrez Gene: 171374 Rat

GenBank: BC016512 Human

Omim: 102910 Human

SwissProt: P00829 Cow

SwissProt: P06576 Human

SwissProt: P56480 Mouse

SwissProt: P10719 Rat

Unigene: 406510 Human

Unigene: 238973 Mouse

Unigene: 92965 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

线粒体ATP合成酶由两个多亚基复合物组成,它们利用膜内电化学梯度催化氧化***酸化过程中ATP的合成。这两个多亚基配合物被指定为F1和F0,前者包括可溶性催化核心,后者包括ATP合成酶的跨膜质子通道。F1由五个不同的亚基组成,分别为ATP5A、ATP5B、ATP5C1、ATP5D和ATP5E,而F0由十个亚基组成,分别为ATP5H、ATP5G1、ATP5I、ATP5G2、ATP5J2、ATP5J、ATP5G3、ATP5S、ATP5F1和ATP5L。ATP5B,也被命名为ATPMB、ATPSB或线粒体ATP合成酶β亚基。一种529氨基酸蛋白,定位于线粒体膜并作为F0复合物的亚基存在。ATP5B由核基因编码,并与线粒体和核基因编码的其他亚基组装。ATP5B基因是由Ets转录因子家族成员激活的,提示ETS转录因子参与了ATP5B基因在高增殖细胞和线粒体蛋白核基因的协调转录中的增强表达。ATP5B mRNA水平在不同的物种中通过转录控制在心脏高表达水平、骨骼肌中的较低水平和肝脏和肾脏的最低水平上有所不同。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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