FITC标记的钙激活钾通道蛋白3抗体上海沪震实业有限公司

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产品名称: FITC标记的钙激活钾通道蛋白3抗体
英文名称: Anti-KCNN3/FITC
抗体货号: HZ-11569R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/8 11:09:00
详细资料:  实验方法技术资料
浏览人数:6
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-KCNN3/FITC Conjugated antibody

FITC标记的钙激活钾通道蛋白3抗体

 

产品编号 bs-11569R-FITC
英文名称 Anti-KCNN3/FITC
中文名称 FITC标记的钙激活钾通道蛋白3抗体
别    名 hSK3; KCa2.3; Kcnn3; KCNN3_HUMAN; Potassium intermediate/small conductance calcium activated channel subfamily N member 3; SK3; SKCa 3; SKCa3; Small conductance calcium-activated potassium channel protein 3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  信号转导  通道蛋白  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNN3 (251-350aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Subunit:
Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding 

Subcellular Location:
Membrane; Multi-pass membrane protein. 

Similarity:
Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.

Database links:

Entrez Gene: 3782 Human

Entrez Gene: 140493 Mouse

Entrez Gene: 54263 Rat

Omim: 602983 Human

SwissProt: Q9UGI6 Human

SwissProt: P58391 Mouse

SwissProt: P70605 Rat

Unigene: 490765 Human

Unigene: 586534 Human

Unigene: 120250 Mouse

Unigene: 10840 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

脊椎动物神经元的动作电位随后伴随着超极化(AHP),这可能持续几秒钟,并可能对神经元的放电模式产生深远的影响。AHP的每个组成部分在动力学上是不同的,并且是由不同的钙激活钾通道介导的。该基因属于KCNN家族钾通道。它编码一个完整的膜蛋白,形成一个与电压无关的钙激活的通道,这被认为通过调节突触AHP的慢成分来调节神经元的兴奋性。该基因在编码序列中含有两个CAG重复区。有人认为,一个或两个重复的扩增可能导致精神分裂症或双相情感障碍的易感性增加,但研究表明,这可能并非如此。另一种编码不同的异构体的剪接转录变体已被发现用于该基因。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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