FITC标记的转录因子HES4抗体上海沪震实业有限公司

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产品名称: FITC标记的转录因子HES4抗体
英文名称: Anti-HES4/FITC
抗体货号: HZ-11567R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/13 13:18:00
详细资料:  实验方法技术资料
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诚信指数:1030点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-HES4/FITC Conjugated antibody

FITC标记的转录因子HES4抗体

 

产品编号 bs-11567R-FITC
英文名称 Anti-HES4/FITC
中文名称 FITC标记的转录因子HES4抗体
别    名 bHLH factor Hes4; Hairy and enhancer of split 4; Transcription factor HES 4; HES4_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HES4 (1-100aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Function:
HES4 may be a transcriptional repressor. It is expressed in stomach, pancreas, ovary, uterus, eye and bone. It has an N-terminal bHLH domain. 

Subunit:
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family

Subcellular Location:
Nuclear

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain. 
Contains 1 Orange domain. 

Database links:
UniProtKB/Swiss-Prot: Q9HCC6.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

果蝇毛状和增强子分裂基因编码基本螺旋-螺旋-螺旋(BHLH)转录阻遏子,在Notch信号通路中起作用,并控制胚胎发育过程中的分割和神经发育。果蝇毛状和增强子分裂的哺乳动物同源物是HES基因家族成员HES1-6,其还编码调节肌肉发生和神经发生的BHLH转录阻遏物。HES家族成员与GLYCHO的哺乳动物同源物TLE形成复合物,并且这种相互作用是由HES蛋白的羧基末端WRPW基序介导的。HES/TLE复合功能是直接与DNA结合,而不是干扰激活蛋白。大多数HES家庭成员,包括HES1和HES5,优先绑定到N盒(CACNAG),而不是E盒(CANTG)。HES2结合N和E盒位点,而HES6不结合DNA。相反,HES6抑制HES1活性,从而促进转录。HES1和HES2在多种***和胚胎组织中表达。HES3仅在小脑浦肯野细胞中表达,而HES5仅存在于神经系统中。HES6在脑中也在发育胚胎的肢芽中产生。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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