FITC标记的GLIS2蛋白抗体
产品名称： FITC标记的GLIS2蛋白抗体
英文名称： Anti-GLIS2/FITC
产品编号： HZ-11566R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
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- 邮箱 : www.shzbio.net
Rabbit Anti-GLIS2/FITC Conjugated antibody
FITC标记的GLIS2蛋白抗体
| 产品编号 | bs-11566R-FITC |
| 英文名称 | Anti-GLIS2/FITC |
| 中文名称 | FITC标记的GLIS2蛋白抗体 |
| 别 名 | NPHP7; NKL; GLI kruppel family member 2; GLI similar 2; GLI-similar 2; GLIS 2; GLIS family zinc finger 2; glis2; GLIS2_HUMAN; Kruppel like zinc finger protein GLIS2; Neuronal Krueppel-like protein; Tax helper protein; THP; Zinc finger protein GLI2; Zinc finger protein GLIS2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 干细胞 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GLIS2 (271-350aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: GLIS2 is a 524 amino acid protein that belongs to the GLI C2H2-type zinc-finger protein family. By recruiting the corepressors CtBP1 and HDAC3, GLIS2 represses the transcriptional activation mediated by ∫-catenin in the Wnt pathway. GLIS2 can act either as a transcription repressor or as a transcription activator and may be involved in neuron differentiation. Mutations of GLIS2 may be associated with development of progressive chronic kidney disease with characteristics resembling nephronophthisis. GLIS2 contains five tandem Cys(2)-His(2) zinc finger motifs that exhibit the highest homology to those of members of the GLI and Zic subfamilies of Krüppel-like proteins. GLIS2 is expressed at high levels in kidney and at low levels in heart, lung and placenta. Function: Can act either as a transcription repressor or as a transcription activator, depending on the cell context. Represses the transcriptional activation mediated by CTNNB1 in the Wnt pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation. Subunit: Interacts with CTBP1 and HDAC3 (By similarity). Interacts with CTNNB1 (By similarity). Interacts with SUFU (By similarity). Interacts with CTNND1. Subcellular Location: Nucleus speckle. Cytoplasm. Tissue Specificity: Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon. Post-translational modifications: C-terminus cleavage is induced by interaction with CTNND1 and enhanced by Src tyrosine kinase DISEASE: Defects in GLIS2 are the cause of nephronophthisis type 7 (NPHP7) [MIM:611498]. NPHP7 is an autosomal recessive disorder resulting in end-stage renal disease during childhood or adolescence. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Similarity: Belongs to the GLI C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers. Database links: UniProtKB/Swiss-Prot: Q9BZE0.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
GLIS2是属于GLI C2H2型锌指蛋白家族的524-氨基酸蛋白。GLIS2通过抑制趋化因子CTBP1和HDAC3抑制Wnt通路中的β-连环蛋白介导的转录激活。GLIS2既可作为转录阻遏物，也可作为转录激活因子，可参与神经元分化。GLIS2的突变可能与进展性慢性肾脏疾病的发展有关，其特征类似于肾功能减退。GLIS2包含5个串联Cys（2-）-HIS2锌指基，其与Krüppel-样蛋白的GLI和ZIC亚家族成员的同源性最高。GLIS2在肾脏中高表达，在心脏、肺和胎盘中表达水平较低。