FITC标记的脊髓性肌萎缩症蛋白SMA抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的脊髓性肌萎缩症蛋白SMA抗体
英文名称: Anti-Gemin 3/FITC
抗体货号: HZ-11563R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/13 16:16:00
详细资料:  实验方法技术资料
浏览人数:4
诚信指数:754点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Gemin 3/FITC Conjugated antibody

FITC标记的脊髓性肌萎缩症蛋白SMA抗体

 

产品编号 bs-11563R-FITC
英文名称 Anti-Gemin 3/FITC
中文名称 FITC标记的脊髓性肌萎缩症蛋白SMA抗体
别    名 Gemin3; Component of gems 3; DDX 20; DDX20; DDX20_HUMAN; DEAD (Asp Glu Ala Asp) box polypeptide 20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD box protein DP103; DEAD-box protein DP103; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 103kD; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20; DEAD/H BOX 20; DKFZP434H052; DP 103; DP103; Gemin-3; Gemin3; Probable ATP dependent RNA helicase DDX20; Probable ATP-dependent RNA helicase DDX20; SMN interacting protein.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  神经生物学  信号转导  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 92kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gemin 3 (101-200aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]. 

Function:
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs.

Subunit:
Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with SMN1 and with several spliceosomal snRNP core Sm proteins, including SNUPN, SNRPB, SNRPD2 and SNRPD3. Interacts with PPP4R2. Interacts with EBV EBNA2 and EBNA3C. Interacts with FOXL2. [SUBCELLULAR LOCATION] Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).

Subcellular Location:
Cytoplasm. Nucleus

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the DEAD box helicase family. DDX20 subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.

Database links:

Entrez Gene: 11218 Human

Entrez Gene: 53975 Mouse

Omim: 606168 Human

SwissProt: Q9UHI6 Human

SwissProt: Q9JJY4 Mouse

Unigene: 591405 Human

Unigene: 272826 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

死盒蛋白,其特征在于保守的基序ASP Glu ALA-ASP(死亡),是假定的RNA解旋酶。它们涉及许多细胞过程,涉及RNA二级结构的改变,如翻译起始、核和线粒体剪接、核糖体和剪接体组装。根据它们的分布模式,该家族的一些成员被认为参与胚胎发生、精子发生和细胞生长和分裂。该基因编码一个死盒蛋白,它具有ATPase活性,是运动神经元(SMN)复合物存活的一个组成部分。这种蛋白直接与SMN,脊髓肌萎缩基因产物相互作用,并可能在RNPs的SMN复合物的功能中发挥催化作用。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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