FITC标记的脊髓性肌萎缩症蛋白SMA抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的脊髓性肌萎缩症蛋白SMA抗体
英文名称: Anti-Gemin 2/FITC
抗体货号: HZ-11562R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/10 14:14:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Gemin 2/FITC Conjugated antibody

FITC标记的脊髓性肌萎缩症蛋白SMA抗体

 

产品编号 bs-11562R-FITC
英文名称 Anti-Gemin 2/FITC
中文名称 FITC标记的脊髓性肌萎缩症蛋白SMA抗体
别    名 SMA; Gemin2; Component of gems 2; Gem (nuclear organelle) associated protein 2; Gem associated protein 2; GEMI2_HUMAN; Gemin-2; gemin2; SIP 1; SIP-1; SIP1; SIP1 delta; SIP1-delta ; SMN interacting protein 1; SMN interacting protein 1 delta; SMN-interacting protein 1; Survival interacting protein 1; Survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gemin 2 (101-200aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011].

Function:
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.

Subunit:
Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN5. 

Subcellular Location:
Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.

Similarity:
Belongs to the gemin-2 family.

Database links:

Entrez Gene: 8487 Human

Entrez Gene: 66603 Mouse

Entrez Gene: 84404 Rat

Omim: 602595 Human

SwissProt: O14893 Human

SwissProt: Q9CQQ4 Mouse

SwissProt: Q9QZP1 Rat

Unigene: 652307 Human

Unigene: 35353 Mouse

Unigene: 34143 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

这个基因编码一个在SMN复合体中发现的蛋白质,它由几个GEMIN蛋白和被称为运动神经元蛋白存活的蛋白质组成。SMN复合物被定位到被称为GEMS(螺旋体的双子)的亚核室,并且需要用于剪接体SNRNPS的组装和预mRNA剪接。这种蛋白直接与运动神经元蛋白的存活相互作用,这是形成SMN复合物所必需的。靶向小鼠基因同源物的敲除小鼠表现出扰乱SNRNP装配和运动神经元变性。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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