FITC标记的甘氨酸受体β/GlyR β抗体
产品名称： FITC标记的甘氨酸受体β/GlyR β抗体
英文名称： Anti-GLRB/FITC
产品编号： HZ-11559R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GLRB/FITC Conjugated antibody
FITC标记的甘氨酸受体β/GlyR β抗体
| 产品编号 | bs-11559R-FITC |
| 英文名称 | Anti-GLRB/FITC |
| 中文名称 | FITC标记的甘氨酸受体β/GlyR β抗体 |
| 别 名 | Glycine receptor 58 kDa subunit; Glycine receptor beta; Glycine receptor subunit beta; Glycine receptor, beta subunit; GLRB_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GLRB (23-110aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: GLRB (Glycine receptor beta) is a neurotransmitter-gated ion channel concentrated within the spinal cord and brainstem. Expression is also observed in several upper brain regions including the cortex, cerebellum, hippocampus and amygdala. Binding of glycine to GLRB increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing), controlling spinal reflexes and locomotor behavior. Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Subunit: Pentamer composed of alpha and beta subunits. Interacts with GPHN Subcellular Location: Plasma membrane; multi-pass membrane protein. DISEASE: Defects in GLRB are the cause of hyperekplexia type 2 (HKPX2) [MIM:614619]. HKPX2 is a neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile2 stimuli. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily. Database links: Entrez Gene: 2743 Human Entrez Gene: 14658 Mouse Entrez Gene: 25456 Rat Omim: 138492 Human SwissProt: P48167 Human SwissProt: P48168 Mouse SwissProt: P20781 Rat Unigene: 32973 Human Unigene: 275639 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
GLRB（甘氨酸受体β）是一种神经递质门控离子通道，集中在脊髓和脑干中。在大脑皮层、小脑、海马和杏仁核等多个脑区也有表达。甘氨酸与GLRB的结合增加了氯离子传导，从而产生超极化（抑制神经元放电），控制脊髓反射和运动行为。