FITC标记的生殖细胞核因子GCNF/维甲酸受体相关睾丸受体抗体
产品名称: FITC标记的生殖细胞核因子GCNF/维甲酸受体相关睾丸受体抗体
英文名称: Anti-GCNF/FITC
产品编号: HZ-11558R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GCNF/FITC Conjugated antibody
FITC标记的生殖细胞核因子GCNF/维甲酸受体相关睾丸受体抗体
产品编号 | bs-11558R-FITC |
英文名称 | Anti-GCNF/FITC |
中文名称 | FITC标记的生殖细胞核因子GCNF/维甲酸受体相关睾丸受体抗体 |
别 名 | GCNF 1; GCNF; GCNF1; Germ cell nuclear factor; hGCNF; hRTR; NR 61; NR61; NR6A1; NR6A1_HUMAN; Nuclear receptor subfamily 6 group A member 1; Orphan nuclear receptor NR6A1; Retinoic acid receptor related testis associated receptor; Retinoid receptor related testis specific receptor; Retinoid receptor-related testis-specific receptor; RTR. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 发育生物学 神经生物学 信号转导 干细胞 转录调节因子 表观遗传学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 54kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human GCNF (251-350aa) |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Germ cell nuclear factor (GCNF) is an orphan member of the nuclear receptor gene superfamily that influences neurogenesis and germ cell development. GCNF can homodimerize and bind DNA. GCNF regulates paracrine interaction between the oocyte and somatic cells by regulating the expression of BMP-15 and GDF-9, to affect female fertility. GCNF is present in spermatocytes and round spermatids of adult male mouse testis; northern blot and ribonuclease protection assays have shown GCNF is predominant in the testis. The gene expresses three alternatively spliced transcript variants. Function: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis. Subunit: Homodimer. Interacts with UIMC1 Subcellular Location: Nucleus. Tissue Specificity: Shows highest expression in the germ cells of the adult testis. Similarity: Belongs to the nuclear hormone receptor family. NR6 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 2649 Human Entrez Gene: 14536 Mouse Entrez Gene: 362125 Rat Omim: 602778 Human SwissProt: Q15406 Human SwissProt: Q64249 Mouse Unigene: 586460 Human Unigene: 439703 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
生殖细胞核因子(GCNF)是核受体基因超家族的孤儿,影响神经发生和生殖细胞发育。GCNF可以同源二聚化并结合DNA。GCNF通过调节BMP-15和GDF-9的表达调节卵母细胞和体细胞间的相互作用,从而影响雌性育性。GCNF存在于成年雄性小鼠睾丸的精母细胞和圆形精子细胞中,Northern印迹和核糖核酸酶保护试验显示GCNF在睾丸中占优势。该基因表达三个交替剪接转录变体。