FITC标记的叉头蛋白G1抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的叉头蛋白G1抗体
英文名称: Anti-FOXG1/FITC
抗体货号: HZ-11557R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/13 16:23:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-FOXG1/FITC Conjugated antibody

FITC标记的叉头蛋白G1抗体

 

产品编号 bs-11557R-FITC
英文名称 Anti-FOXG1/FITC
中文名称 FITC标记的叉头蛋白G1抗体
别    名 BF 1; BF 2; BF-1; BF-2; BF1; BF2 ; Brain factor 1; Brain factor 2; FHKL; FKH2; FKHL1; FKHL2; FKHL2; FKHL3; FKHL4; Forkhead box G1A; Forkhead box G1B; Forkhead box protein G1; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; Forkhead drosophila homolog like 2; Forkhead like 1; Forkhead like 2; FOXG1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FOXG1 (201-300aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The winged-helix transcriptional repressor (WH) BF-1 gene encodes brain factor 1 (BF-1), also known as foxg1, and is essential for the proliferation of progenitor cells in the cerebral cortex and influences regional patterning in the mammalian telencephalon (1–4). WH proteins are a family of putative transcriptional regulators with diverse roles in development, and are characterized by a highly conserved DNA binding structure, the WH domain (1,5,6). BF-1 plays a critical role in the development of the cerebral hemispheres of the brain and targeted disruption of the gene leads to severe defects in the development of telencephalic structures, such as the cerebral cortex and basal ganglia (1). The loss of BF-1 results in an accelerated rate of neuronal differentiation and the shortening of the neurogenetic period in the embryonic cerebral cortex (1,7). BF-1 is expressed by E8.5 in telencephalic progenitors (1). It may also regulate the response of cerebral cortical progenitors to environmental cues (1).

Function:
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.

Subunit:
Interacts with KDM5B.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expression is restricted to the neurons of the developing telencephalon.

DISEASE:
Defects in FOXG1 are the cause of congenital variant of Rett syndrome (RTTCV) [MIM:613454]. RTTCV is a severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements.

Similarity:
Contains 1 fork-head DNA-binding domain.

Database links:

Entrez Gene: 2290 Human

Entrez Gene: 15228 Mouse

Omim: 164874 Human

SwissProt: P55316 Human

SwissProt: Q60987 Mouse

Unigene: 695962 Human

Unigene: 708841 Human

Unigene: 4704 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
   

有翼螺旋转录阻遏物(WH)BF-1基因编码脑因子1(BF-1),也称为FXG1,是大脑皮层祖细胞增殖所必需的,并影响哺乳动物端脑(1~4)区域构型。WH蛋白是一类具有不同发育功能的转录调控因子家族,其特征是高度保守的DNA结合结构WH结构域(1,5,6)。BF-1在脑半球的发育中起着关键性的作用,靶基因的破坏导致脑皮质和基底神经节发育的严重缺陷(1)。BF-1的丢失导致胚胎大脑皮层(1,7)神经元分化的加速率和神经发生期的缩短。BF-1通过E8.5在端脑祖细胞中表达(1)。它还可以调节大脑皮质祖细胞对环境线索的反应(1)。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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