Rabbit Anti-Dispatched/FITC Conjugated antibody
|别 名||DISP1; DISP 1; disp1; DISP1_HUMAN; DISPA; Dispatched A; Dispatched homolog 1; DKFZP434I0428; FLJ43740; MGC104180; MGC13130; MGC16796; Protein dispatched homolog 1.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||信号转导 转运蛋白 细胞膜蛋白|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||171kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human Dispatched (301-400aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal
Membrane; Multi-pass membrane protein
Belongs to the dispatched family.
Contains 1 SSD (sterol-sensing) domain.
Entrez Gene: 84976 Human
Entrez Gene: 68897 Mouse
Omim: 607502 Human
SwissProt: Q96F81 Human
SwissProt: Q3TDN0 Mouse
Unigene: 528817 Human
Unigene: 358721 Mouse
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications