FITC标记的磷脂蛋白受体Dab1抗体-抗体-抗体-生物在线
FITC标记的磷脂蛋白受体Dab1抗体

FITC标记的磷脂蛋白受体Dab1抗体

商家询价

产品名称: FITC标记的磷脂蛋白受体Dab1抗体

英文名称: Anti-Dab1/FITC

产品编号: HZ-11547R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
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  • 邮箱 : www.shzbio.net

 Rabbit Anti-Dab1/FITC Conjugated antibody

FITC标记的磷脂蛋白受体Dab1抗体

 

产品编号 bs-11547R-FITC
英文名称 Anti-Dab1/FITC
中文名称 FITC标记的磷脂蛋白受体Dab1抗体
别    名 Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari; Dab, reelin signal transducer, homolog 1 (Drosophila); Dab1; DAB1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dab1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Function:
Adapter molecule functioning in neural development. May regulate SIAH1 activity.

Subunit:
Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1. Interacts with LRP1.

Post-translational modifications:
Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.

Similarity:
Contains 1 PID domain.

Database links:

Entrez Gene: 1600 Human

Entrez Gene: 13131 Mouse

Entrez Gene: 266729 Rat

Entrez Gene: 374083 Chicken

Omim: 603448 Human

SwissProt: O75553 Human

SwissProt: P97318 Mouse

SwissProt: Q8CJH2 Rat

Unigene: 477370 Human

Unigene: 289682 Mouse

Unigene: 206534 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

大脑皮层中多个神经元类型的层级组织是正常认知功能所必需的。在小鼠中,Dababel-1基因在脑发育中起着中心作用,引导皮层神经元迁移到先前形成的神经元以达到其适当的层。该基因与Dababel-1相似,并且该基因编码的蛋白被认为是与蛋白激酶通路相互作用的信号转导子,以调节发育中的大脑中的神经元定位。选择性地报道了该基因的剪接转录变体,但其全长性质尚未确定。