FITC标记的Centaurin α1抗体上海沪震实业有限公司

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产品名称: FITC标记的Centaurin α1抗体
英文名称: Anti-Centaurin alpha 1/FITC
抗体货号: HZ-11543R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/4 13:09:00
详细资料:  实验方法技术资料
浏览人数:13
诚信指数:1034点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
021-60345367
传真:
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陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-Centaurin alpha 1/FITC Conjugated antibody

FITC标记的Centaurin α1抗体

 

产品编号 bs-11543R-FITC
英文名称 Anti-Centaurin alpha 1/FITC
中文名称 FITC标记的Centaurin α1抗体
别    名 ArfGAP with dual PH domains 1; CENTA 1; CENTA1; Centaurin alpha; GCS1L; IP4/PIP3 binding protein; p42IP4; Putative MAPK activating protein PM25; ADAP1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Centaurin alpha 1 (101-200aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.

Function:
The centaurin alpha 1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), centaurin alpha 1 is able to switch off ARF6 and inhibit its ability to mediate beta 2 adrenoceptor internalization and negatively regulates ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.

Subunit:
Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1. 

Subcellular Location:
Cellular localizationCytoplasmic, Nuclear and Plasma membrane

Tissue Specificity:
Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes. 

Post-translational modifications:
Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro. 

Similarity:
Contains 1 Arf-GAP domain. 
Contains 2 PH domains. 

Database links:
UniProtKB/Swiss-Prot: O75689.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

ADP核糖基化因子(ARF)家族的小GTP结合蛋白参与囊泡运输调控和控制细胞骨架组织和细胞粘附。这些蛋白质的最佳特征是膜交通的调节器。半人马豆素GTP酶激活蛋白家族包括一个ARF调节分子的子集,其将PI 3-激酶激活转导成ARF依赖性通路的协调控制。该家族包括ASAP1、ACAP1、ACAP2、AGAP1、ARAP1、ARAP2、矢车菊素A1和矢车菊素G3。矢车菊素A1蛋白是一种高亲和力的PtdIns(3,4,5)P3结合蛋白,富含脑组织。通过作为ADP-核糖基化因子6(ARF6)的GTPASE激活蛋白,矢车菊素A1能够切断ARF6并抑制其介导B2***受体内化的能力,并通过体内PIP3依赖的ARF6间隙发挥负调节ARF6活性。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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