FITC标记的钙调神经磷酸酶调节蛋白3抗体（唐氏综合征候选区域蛋白1样蛋白3）
产品名称： FITC标记的钙调神经磷酸酶调节蛋白3抗体（唐氏综合征候选区域蛋白1样蛋白3）
英文名称： Anti-Calcipressin 3/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Calcipressin 3/FITC Conjugated antibody
FITC标记的钙调神经磷酸酶调节蛋白3抗体（唐氏综合征候选区域蛋白1样蛋白3）
| 产品编号 | bs-11542R-FITC |
| 英文名称 | Anti-Calcipressin 3/FITC |
| 中文名称 | FITC标记的钙调神经磷酸酶调节蛋白3抗体（唐氏综合征候选区域蛋白1样蛋白3） |
| 别 名 | Calcipressin-3; Down syndrome candidate region 1 like 2; regulator of calcineurin 3; Down syndrome candidate region 1 like protein 2; Down syndrome candidate region 1-like protein 2; Down syndrome critical region gene 1 like 2; DSCR1L2; hRCN3; MCIP3; Myocyte enriched calcineurin interacting protein 3; Myocyte-enriched calcineurin-interacting protein 3; RCAN family member 3; RCAN3; RCAN3_HUMAN; RCN3; RCN3; MCIP3; Regulator of calcineurin 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Calcipressin 3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events. Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Tissue Specificity: Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues. Similarity: Belongs to the RCAN family. Database links: Entrez Gene: 11123 Human Entrez Gene: 53902 Mouse Omim: 605860 Human SwissProt: Q9UKA8 Human SwissProt: Q9JKK0 Mouse Unigene: 656799 Human Unigene: 331970 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Calcineurin是一种于多种神经功能的钙（2 +）性蛋白磷酸酶。属于RCAN（钙调神经磷酸酶）调节蛋白家族的蛋白质通过其羧基尾内富含缬氨酸的区域调节Calcineurin的活性。RCANs与NFATs（激活的T细胞的核因子）竞争，结合到钙调神经磷酸酶中的相同的对接位点，从而导致钙调神经磷酸酶活性的抑制或激活。钙化蛋白-2，也被称为RCAN2和DSCR1L1（唐氏综合征候选区域1样1），是一种197个氨基酸蛋白，在神经元的细胞质和细胞核中都高度表达，并且是在胶质细胞中发现的唯一的RCAN家族成员。钙化蛋白-3，也称为RCAN3和DSCR1L2（唐氏综合征候选区域1样蛋白2），是一种潜在参与中枢神经系统发育的241氨基酸蛋白。钙化蛋白-3与心肌肌钙蛋白I相互作用，提示它可能在心脏收缩事件中起作用。