FITC标记的钙调神经磷酸酶调节蛋白3抗体(唐氏综合征候选区域蛋白1样蛋白3)上海沪震实业有限公司

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产品名称: FITC标记的钙调神经磷酸酶调节蛋白3抗体(唐氏综合征候选区域蛋白1样蛋白3)
英文名称: Anti-Calcipressin 3/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/1 13:40:00
详细资料:  实验方法技术资料
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诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-Calcipressin 3/FITC Conjugated antibody

FITC标记的钙调神经***酸酶调节蛋白3抗体(唐氏综合征候选区域蛋白1样蛋白3)

 

产品编号 bs-11542R-FITC
英文名称 Anti-Calcipressin 3/FITC
中文名称 FITC标记的钙调神经***酸酶调节蛋白3抗体(唐氏综合征候选区域蛋白1样蛋白3)
别    名 Calcipressin-3; Down syndrome candidate region 1 like 2; regulator of calcineurin 3; Down syndrome candidate region 1 like protein 2; Down syndrome candidate region 1-like protein 2; Down syndrome critical region gene 1 like 2; DSCR1L2; hRCN3; MCIP3; Myocyte enriched calcineurin interacting protein 3; Myocyte-enriched calcineurin-interacting protein 3; RCAN family member 3; RCAN3; RCAN3_HUMAN; RCN3; RCN3; MCIP3; Regulator of calcineurin 3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Calcipressin 3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events.

Function:
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

Tissue Specificity:
Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.

Similarity:
Belongs to the RCAN family.

Database links:

Entrez Gene: 11123 Human

Entrez Gene: 53902 Mouse

Omim: 605860 Human

SwissProt: Q9UKA8 Human

SwissProt: Q9JKK0 Mouse

Unigene: 656799 Human

Unigene: 331970 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

Calcineurin是一种于多种神经功能的钙(2 +)性蛋***酸酶。属于RCAN(钙调神经***酸酶)调节蛋白家族的蛋白质通过其羧基尾内富含缬氨酸的区域调节Calcineurin的活性。RCANs与NFATs(激活的T细胞的核因子)竞争,结合到钙调神经***酸酶中的相同的对接位点,从而导致钙调神经***酸酶活性的抑制或激活。钙化蛋白-2,也被称为RCAN2和DSCR1L1(唐氏综合征候选区域1样1),是一种197个氨基酸蛋白,在神经元的细胞质和细胞核中都高度表达,并且是在胶质细胞中发现的唯一的RCAN家族成员。钙化蛋白-3,也称为RCAN3和DSCR1L2(唐氏综合征候选区域1样蛋白2),是一种潜在参与中枢神经系统发育的241氨基酸蛋白。钙化蛋白-3与心肌肌钙蛋白I相互作用,提示它可能在心脏收缩事件中起作用。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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