FITC标记的信号转导蛋白9复合体7b抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的信号转导蛋白9复合体7b抗体
英文名称: Anti-CSN7b/FITC
抗体货号: HZ-11540R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/13 16:39:00
详细资料:  实验方法技术资料
浏览人数:6
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-CSN7b/FITC Conjugated antibody

FITC标记的信号转导蛋白9复合体7b抗体

 

产品编号 bs-11540R-FITC
英文名称 Anti-CSN7b/FITC
中文名称 FITC标记的信号转导蛋白9复合体7b抗体
别    名 COP9 Complex Homolog Subunit 7b; COP9 Constitutive Photomorphogenic Homolog Subunit 7b; COP9 Signalasome Subunit 7b; COP9 signalosome complex subunit 7b; COPS7B; CSN7B_HUMAN; JAB1 Containing Signalosome Subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; Signalosome subunit 7b.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CSN7b (201-264aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I˚Bå and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.

Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Subunit:
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8.

Subcellular Location:
Cytoplasm. Nucleus.

Similarity:
Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Contains 1 PCI domain.

Database links:
UniProtKB/Swiss-Prot: Q9H9Q2.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

COP9信号体(CSN)复合物参与了几种不同的发育和细胞过程。该复合物由几个广泛表达的蛋白质组成:CSN1(COPS1)、CSN2(COPS2)、CSN3(COPS3)、CSN4(COPS4)、CSN5(COPS5)、CSN6(COP6)、CSN7A(COPS7、COPS7A)或CSN7B(COP7B)和CSN8(COP8)。CSN络合物通过介导SCF型E3连接酶复合物的去乙酰化作用,作为泛素缀合途径的调节器,从而导致SCF复合物泛素连接酶活性降低。它还参与了p53、c-jun、Ii b b和IrF 8的***酸化以及p53的CSN依赖性***酸化,c-jun通过UBL系统保护和促进降解。CsN7由CK2***酸化,由两个亚基组成;A和B CSN7A包含PCI(蛋白酶体CSN9启动因子3)区域,以及卷曲螺旋区,并预测与CsN2、CSN3、CSN4、CSN5、CSN6、CSN8和GPS1相互作用。CSN7B仅包含PCI区域,并预测与It6交互。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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