FITC标记的小脑肽3抗体
产品名称： FITC标记的小脑肽3抗体
英文名称： Anti-CBLN3/FITC
产品编号： HZ-11537R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-CBLN3/FITC Conjugated antibody
FITC标记的小脑肽3抗体
| 产品编号 | bs-11537R-FITC |
| 英文名称 | Anti-CBLN3/FITC |
| 中文名称 | FITC标记的小脑肽3抗体 |
| 别 名 | Cbln3; Cbln 3; Cbln-3; CBLN3_HUMAN; Cerebellin-3; Cerebellin3; Cerebellin 3; PRO1486. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cerebellin 3 (101-200aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other’s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases. Function: May be involved in synaptic functions in the CNS. Subunit: Heterohexamer; disulfide-linked heterotrimers. Does not homooligomerize, but probably forms a complex with at least CBLN1. May interact with CBLN2 and CBLN4 Subcellular Location: Secreted. Cell junction, synapse (By similarity). Note=Secretion depends probably on a association with CBLN1 or perhaps CBLN4 but not on CBLN2 Similarity: Contains 1 C1q domain. Database links: Entrez Gene: 643866 Human Entrez Gene: 56410 Mouse Omim: 612978 Human SwissProt: Q6UW01 Human SwissProt: Q9JHG0 Mouse Unigene: 207603 Human Unigene: 97163 Mouse
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Cerebellin（CER），最初是从大鼠小脑中分离出来的，是由一个被称为小脑蛋白1的更大的前体衍生的十六肽，也被命名为前小脑蛋白1或CBLN1。四个前肽，小脑蛋白1，小脑蛋白2（CBLN2），Cerebellin 3（CBLN3）和Cerebellin 4（CBLN4），包括C1q蛋白家族中的前小脑素亚家族。Cerebellin家族成员在不同脑区作为突触发育和突触可塑性的跨神经元调节器。Cerebellin及其代谢物，des Ser（1）CER，也表达在几个额外的小脑组织，包括肾上腺。小脑蛋白1, 2和3组装成同型异构体和多聚体，从而影响彼此的降解和分泌。小脑蛋白3不能形成同型复合体，并且只能在与小脑蛋白1形成异构化复合物时分泌。脑桥小脑萎缩（OPCA）和Sy-Danger-Survivin综合征患者脑内小脑蛋白浓度降低，提示Cerebellin在这些疾病的病理学中起一定作用。