FITC标记的TUB蛋白抗体
产品名称： FITC标记的TUB蛋白抗体
英文名称： Anti-TUB 1/FITC
产品编号： HZ-11536R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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- 邮编 : 200612
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Rabbit Anti-TUB 1/FITC Conjugated antibody
FITC标记的TUB蛋白抗体
| 产品编号 | bs-11536R-FITC |
| 英文名称 | Anti-TUB 1/FITC |
| 中文名称 | FITC标记的TUB蛋白抗体 |
| 别 名 | F10B5.4; rd5; TUB 1; TUB; TUB_HUMAN; Tubby homologue; Tubby protein homolog 1; Tubby protein homolog. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TUB 1 (241-305aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4). Function: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Subunit: Interacts with GNAQ (By similarity). Interacts with TULP1 Subcellular Location: Cytoplasm. Nucleus. Secreted. Cell membrane. Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. Similarity: Belongs to the TUB family. Database links: UniProtKB/Swiss-Prot: P50607.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
与OB/ob小鼠（1-3）中所见的快速早发性体重增加相反，TUB基因的突变逐渐导致肥胖，并与人类群体（4）中的晚发性肥胖强烈相似。除了脂肪组织的过度沉积外，具有盆腔表型的小鼠也有视网膜变性和神经感觉性听力损失（4-6）。TUBBY表型的三重特征与人类肥胖综合征有显著的相似性，如阿尔斯特罗（5）和Bardet Biedl（6）。已经描述了用于桶基因的候选（4）。该候选基因中的G颠倒消除了在3′编码区中的供体剪接位点，导致包含未剪接内含子（4）的更大转录本。与B6小鼠（4）相比，在未经剪接的内含子中发现第二个过早截短的mRNA转录物，以2-3倍的速率在TUBBY小鼠的脑中表达。据推测，TUBY小鼠的表型特征可归因于突变的TUB基因（4）的表达所触发的细胞凋亡。