FITC标记的蛋白酪氨酸磷酸酶样N前体蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的蛋白酪氨酸磷酸酶样N前体蛋白抗体
英文名称: Anti-PTPRN/FITC
抗体货号: HZ-11532R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/9 14:22:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-PTPRN/FITC Conjugated antibody

FITC标记的蛋白酪氨酸***酸酶样N前体蛋白抗体

 

产品编号 bs-11532R-FITC
英文名称 Anti-PTPRN/FITC
中文名称 FITC标记的蛋白酪氨酸***酸酶样N前体蛋白抗体
别    名 PTPIA2; RPTPN; TPIA2; CA 512; IA 2; IA 2/PTP; IA2; IA2/PTP; ICA 3; ICA 512; ICA3; ICA512; Islet cell antigen 2; Islet cell antigen 512; Islet cell autoantigen 3; Protein tyrosine phosphatase like N; Protein tyrosine phosphatase like N precursor; Protein tyrosine phosphatase receptor type N; PTP IA 2; PTP IA-2; PTP IA2; PTPIA 2; PTPN; Ptprn; PTPRN protein; PTPRN_HUMAN; R PTP N; R-PTP-N; Receptor type tyrosine protein phosphatase like N; Receptor-type tyrosine-protein phosphatase-like N.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  神经生物学  信号转导  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Sheep, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 102kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TPIA2 (501-600aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

Function:
Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. 

Subunit:
Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage. 

Subcellular Location:
Membrane. Neuroendocrine secretory granules.

Tissue Specificity:
Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary.

Post-translational modifications:
Appears to undergo multiple proteolytic cleavage at consecutive basic residues.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
Contains 1 tyrosine-protein phosphatase domain.

Database links:

Entrez Gene: 5798 Human

Entrez Gene: 19275 Mouse

Entrez Gene: 116660 Rat

Entrez Gene: 286810 Cow

Omim: 601773 Human

SwissProt: P56722 Cow

SwissProt: Q16849 Human

SwissProt: Q60673 Mouse

SwissProt: Q63259 Rat

Unigene: 89655 Human

Unigene: 2902 Mouse

Unigene: 11097 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

由该基因编码的蛋白质是蛋白酪氨酸***酸酶(PTP)家族的成员。PTPs已知是调节多种细胞过程的信号分子,包括细胞生长、分化、有丝分裂周期和致癌转化。该PTP具有细胞外区域、单个跨膜区域和单个催化结构域,因此代表受体型PTP。该PTP是一种与胰岛素依赖型糖尿病(IDDM)患者血清反应的自身抗原,因此可能是糖尿病自身免疫的潜在靶点。交替剪接导致多种转录变异

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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