FITC标记的神经肽W抗体
产品名称: FITC标记的神经肽W抗体
英文名称: Anti-NPW/Neuropeptide W/FITC
产品编号: HZ-11531R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NPW/Neuropeptide W/FITC Conjugated antibody
FITC标记的神经肽W抗体
产品编号 | bs-11531R-FITC |
英文名称 | Anti-NPW/Neuropeptide W/FITC |
中文名称 | FITC标记的神经肽W抗体 |
别 名 | hPPL8; L8; L8C; Neuropeptide W; PPL8; PPNPW; Preproprotein L8; NPW_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 神经生物学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Cow, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 3kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Neuropeptide W (33-55aa) |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: NPW is a 165 amino acid secreted protein that is cleaved into two chains: neuropeptide W-23 (also designated NPW23 or L8) and neuropeptide W-30 (also known as NPW30 or L8C). Both NPW neuropeptides activate G-protein coupled receptors in the central nervous system to enhance cortisol secretion. Highly expressed in lymphoblastic leukemia, colorectal adenocarcinoma, fetal kidney, trachea and substantia nigra, NPW is also found at low levels in placenta, ovary, testis and uterus. NPW functions in organization of neuroendocrine signals and is also thought to enhance food and water intake as well as stress responses. The gene encoding NPW maps to human chromosome 16p13.3. Function: NPW is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. Subcellular Location: Secreted Tissue Specificity: Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma. Similarity: Belongs to the neuropeptide B/W family. Database links: Entrez Gene: 283869 Human Omim: 607997 Human SwissProt: Q8N729 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NPW是一种165氨基酸分泌蛋白,被裂解成两条链:神经肽W-23(也被命名为NPW23或L8)和神经肽W-30(也称为NPW30或L8C)。两个NPW神经肽激活中枢神经系统中的G蛋白偶联受体以增强皮质醇分泌。在淋巴母细胞白血病、结直肠腺癌、胎儿肾脏、气管和黑质中高表达,NPW在胎盘、卵巢、睾丸和子宫中也低水平。NPW在神经内分泌信号的组织中起作用,并被认为可以增强食物和水分的摄入以及应激反应。编码NPW的基因定位于人类染色体16p133。