FITC标记的受体蛋白酪氨酸磷酸酶F抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的受体蛋白酪氨酸磷酸酶F抗体
英文名称: Anti-LAR/FITC
抗体货号: HZ-11530R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 8:37:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-LAR/FITC Conjugated antibody

FITC标记的受体蛋白酪氨酸***酸酶F抗体

 

产品编号 bs-11530R-FITC
英文名称 Anti-LAR/FITC
中文名称 FITC标记的受体蛋白酪氨酸***酸酶F抗体
别    名 LAR; LAR protein; LARFN5C; PTPRF; LARS; LCA homolog; Leukocyte antigen related (LAR) PTP receptor; Leukocyte antigen related; Leukocyte antigen related PTP receptor; Leukocyte antigen related tyrosine phosphatase; Leukocyte common antigen related; Protein Tyrosine Phosphatase Receptor Type F; Protein tyrosine phosphatase receptor type F polypeptide; Ptprf; PTPRF protein; PTPRF_HUMAN; Receptor linked protein tyrosine phosphatase LAR; Receptor type tyrosine protein phosphatase F; Receptor type tyrosine protein phosphatase F precursor; Receptor-type tyrosine-protein phosphatase F.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  信号转导  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 210kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPRF (30-100aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Function:
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity. 
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. 

Subunit:
Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.

Subcellular Location:
Membrane; Single-pass type I membrane protein. 

Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Contains 8 fibronectin type-III domains.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 tyrosine-protein phosphatase domains.

Database links:

Entrez Gene: 5792 Human

Entrez Gene: 19268 Mouse

Entrez Gene: 360406 Rat

Entrez Gene: 12072 Cow

Omim: 179590 Human

SwissProt: P10586 Human

SwissProt: Q5T021 Human

SwissProt: Q5T022 Human

SwissProt: Q86WS0 Human

SwissProt: A2A8L5 Mouse

SwissProt: Q9EQ17 Mouse

SwissProt: Q64604 Rat

Unigene: 272062 Human

Unigene: 29855 Mouse

Unigene: 11386 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

由该基因编码的蛋白质是蛋白酪氨酸***酸酶(PTP)家族的成员。PTPs已知是调节多种细胞过程的信号分子,包括细胞生长、分化、有丝分裂周期和致癌转化。该PTP具有胞外区、单个跨膜区和两个串联胞质内催化域,因此代表受体型PTP。细胞外区域包含三个Ig样结构域,九个类似于神经细胞粘附分子的非Ig样结构域。该PTP被证明在调节粘附细胞上皮细胞-细胞接触,以及β-连环蛋白信号转导的调控中起作用。该蛋白在肥胖、胰岛素抵抗个体的胰岛素应答组织中表达增加,并可能参与胰岛素抵抗的发病机制。报道了这两个编码不同蛋白的基因的剪接变异体。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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