FITC标记的酪氨酸单氧化酶微管相关蛋白MICAL抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的酪氨酸单氧化酶微管相关蛋白MICAL抗体
英文名称: Anti-MICAL1/FITC
抗体货号: HZ-11525R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 8:42:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-MICAL1/FITC Conjugated antibody

FITC标记的酪氨酸单氧化酶微管相关蛋白MICAL抗体

 

产品编号 bs-11525R-FITC
英文名称 Anti-MICAL1/FITC
中文名称 FITC标记的酪氨酸单氧化酶微管相关蛋白MICAL抗体
别    名 Alternative namesCasL interacting molecule; MICA1_HUMAN; MICAL 1; MICAL; MICAL1; microtubule associated monoxygenase, calponin and LIM domain containing 1 antibody Molecule interacting with CasL protein 1; NEDD9 interacting protein with calponin homology and LIM domains; NEDD9-interacting protein with calponin homology and LIM domains; NICAL.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 119kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MICAL1 (101-200aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
MICAL1 is a 1,067 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Expressed in kidney, thymus, spleen, lung and testis, MICAL1 interacts with the SH3 domain of Cas-L and, via this interaction, is thought to function as a cytoskeletal regulator that connects Cas-L to intermediate filaments. MICAL1 also interacts with Rab 1B, plexin-A3 and Vimentin, further regulating cytoskeletal events and possibly playing a role in axonal repulsion. Three isoforms of MICAL1 exist due to alternative splicing events.

Function:
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. 

Subunit:
Interacts with STK38 and STK38L (By similarity). Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. 

Tissue Specificity:
Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. 

Similarity:
Belongs to the Mical family.
Contains 1 CH (calponin-homology) domain. 
Contains 1 LIM zinc-binding domain. 

Database links:
UniProtKB/Swiss-Prot: Q8TDZ2.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

MICAL1是一种定位于细胞质和细胞骨架的1067氨基酸蛋白,包含一个LIM锌结合结构域和一个Calpin同源结构域。在肾脏、胸腺、脾脏、肺和睾丸中表达,MICAL1与CAS-1的SH3结构域相互作用,通过这种相互作用,被认为是连接CAS-1至中间丝的细胞骨架调节器。MICAL1还与RAB 1B、丛蛋白A3和波形蛋白相互作用,进一步调节细胞骨架事件,并可能在轴突排斥中起作用。MIAL1的3种异构体由于选择性剪接事件而存在。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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