Rabbit Anti-MICAL1/FITC Conjugated antibody
|别 名||Alternative namesCasL interacting molecule; MICA1_HUMAN; MICAL 1; MICAL; MICAL1; microtubule associated monoxygenase, calponin and LIM domain containing 1 antibody Molecule interacting with CasL protein 1; NEDD9 interacting protein with calponin homology and LIM domains; NEDD9-interacting protein with calponin homology and LIM domains; NICAL.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 神经生物学 信号转导|
|交叉反应||Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||119kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human MICAL1 (101-200aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
MICAL1 is a 1,067 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Expressed in kidney, thymus, spleen, lung and testis, MICAL1 interacts with the SH3 domain of Cas-L and, via this interaction, is thought to function as a cytoskeletal regulator that connects Cas-L to intermediate filaments. MICAL1 also interacts with Rab 1B, plexin-A3 and Vimentin, further regulating cytoskeletal events and possibly playing a role in axonal repulsion. Three isoforms of MICAL1 exist due to alternative splicing events.
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.
Interacts with STK38 and STK38L (By similarity). Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B.
Cytoplasm. Cytoplasm, cytoskeleton.
Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
Belongs to the Mical family.
Contains 1 CH (calponin-homology) domain.
Contains 1 LIM zinc-binding domain.
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications