FITC标记的酪氨酸单氧化酶微管相关蛋白MICAL抗体
产品名称： FITC标记的酪氨酸单氧化酶微管相关蛋白MICAL抗体
英文名称： Anti-MICAL1/FITC
产品编号： HZ-11525R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-MICAL1/FITC Conjugated antibody
FITC标记的酪氨酸单氧化酶微管相关蛋白MICAL抗体
| 产品编号 | bs-11525R-FITC |
| 英文名称 | Anti-MICAL1/FITC |
| 中文名称 | FITC标记的酪氨酸单氧化酶微管相关蛋白MICAL抗体 |
| 别 名 | Alternative namesCasL interacting molecule; MICA1_HUMAN; MICAL 1; MICAL; MICAL1; microtubule associated monoxygenase, calponin and LIM domain containing 1 antibody Molecule interacting with CasL protein 1; NEDD9 interacting protein with calponin homology and LIM domains; NEDD9-interacting protein with calponin homology and LIM domains; NICAL. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 119kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MICAL1 (101-200aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MICAL1 is a 1,067 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Expressed in kidney, thymus, spleen, lung and testis, MICAL1 interacts with the SH3 domain of Cas-L and, via this interaction, is thought to function as a cytoskeletal regulator that connects Cas-L to intermediate filaments. MICAL1 also interacts with Rab 1B, plexin-A3 and Vimentin, further regulating cytoskeletal events and possibly playing a role in axonal repulsion. Three isoforms of MICAL1 exist due to alternative splicing events. Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Subunit: Interacts with STK38 and STK38L (By similarity). Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Tissue Specificity: Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. Similarity: Belongs to the Mical family. Contains 1 CH (calponin-homology) domain. Contains 1 LIM zinc-binding domain. Database links: UniProtKB/Swiss-Prot: Q8TDZ2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MICAL1是一种定位于细胞质和细胞骨架的1067氨基酸蛋白，包含一个LIM锌结合结构域和一个Calpin同源结构域。在肾脏、胸腺、脾脏、肺和睾丸中表达，MICAL1与CAS-1的SH3结构域相互作用，通过这种相互作用，被认为是连接CAS-1至中间丝的细胞骨架调节器。MICAL1还与RAB 1B、丛蛋白A3和波形蛋白相互作用，进一步调节细胞骨架事件，并可能在轴突排斥中起作用。MIAL1的3种异构体由于选择性剪接事件而存在。