FITC标记的胚胎神经细胞NNAT抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的胚胎神经细胞NNAT抗体
英文名称: Anti-Neuronatin/FITC
抗体货号: HZ-11519R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 8:51:00
详细资料:  实验方法技术资料
浏览人数:10
诚信指数:820点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Neuronatin/FITC Conjugated antibody

FITC标记的胚胎神经细胞NNAT抗体

 

产品编号 bs-11519R-FITC
英文名称 Anti-Neuronatin/FITC
中文名称 FITC标记的胚胎神经细胞NNAT抗体
别    名 Neuronatin; Nnat; NNAT_HUMAN; Peg 5; Peg5.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  发育生物学  神经生物学  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 9kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neuronatin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The paternally imprinted Neuronatin gene (NNAT) is initially expressed in rhombomeres and the pituitary gland and is later expressed more widely, but much less abundantly, in the central and peripheral nervous systems. The human NNAT gene maps to chromosome 20q11.23 and contains an imprinting region associated with morphological abnormalities and early neonatal lethality. Specifically, hypermethylation of the NNAT gene occurs in both myeloid and lymphoid acute pediatric leukemias and may inhibit NNAT expression. The Neuronatin protein consists of two isoforms, alpha and beta, which are the products of alternative splicing. The alpha form of the Neuronatin gene is encoded by three exons, whereas the beta form is missing the second exon. Neuronatin mRNA expression is abundant in undifferentiated PC-12 cells. Treatment of these cells with nerve growth factor (NGF), which contributes to neuronal differentiation, downregulates Neuronatin mRNA expression. NNAT (-) 1.9 PC-12 cells exhibit an increase in nigericin, rotenone and valinomcin sensitivity; NNAT transfection restores wild-type PC-12 resistance. These results suggests a potential protective role for Neuronatin against toxic insult during development.

Function:
May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.

Similarity:
Belongs to the neuronatin family.

Database links:

Entrez Gene: 4826 Human

Entrez Gene: 18111 Mouse

Entrez Gene: 94270 Rat

Omim: 603106 Human

SwissProt: Q16517 Human

SwissProt: Q61979 Mouse

SwissProt: Q62649 Rat

Unigene: 504703 Human

Unigene: 34330 Mouse

Unigene: 5785 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

父本印记神经氨酸酶基因(NNAT)最初表达于菱形和垂体,后来在中枢和外周神经系统中表达更为广泛,但却少得多。人类NNAT基因映射到染色体20q1.23,并包含与形态学异常和早期新生儿致死相关的印迹区域。具体而言,NNAT基因的甲基化发生在髓性和淋巴性急性儿童白血病中,并可能抑制NNAT表达。神经氨酸蛋白由两种异构体组成,即α和β,它们是选择性剪接的产物。NoNANTIN基因的alpha形式由三个外显子编码,而β型缺失第二外显子。未分化PC-12细胞中神经氨酸mRNA表达丰富。用神经生长因子(NGF)治疗这些细胞,这有助于神经元分化,下调神经突触素mRNA的表达。NNAT(-)1.9 PC-12细胞表现出尼日利亚素、鱼藤***和缬氨霉素敏感性的增加;NNAT转染恢复野生型PC-12抗性。这些结果表明神经保护素在开发过程中对毒性侮辱具有潜在的保护作用。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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