FITC标记的脂肪酸脱氢酶2抗体上海沪震实业有限公司

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产品名称: FITC标记的脂肪酸脱氢酶2抗体
英文名称: Anti-FADS2/FITC
抗体货号: HZ-11516R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/23 10:27:00
详细资料:  实验方法技术资料
浏览人数:10
诚信指数:1034点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-FADS2/FITC Conjugated antibody

FITC标记的脂肪酸脱氢酶2抗体

 

产品编号 bs-11516R-FITC
英文名称 Anti-FADS2/FITC
中文名称 FITC标记的脂肪酸脱氢酶2抗体
别    名 D6D; Delta(6) desaturase; Delta(6) fatty acid desaturase; DES 6; DES6; FADS 2; FADSD 6; FADSD6; Fatty acid desaturase 2; linoleoyl-CoA desaturase (delta-6-desaturase) like 2; LLCDL 2; LLCDL2; SLL0262; TU 13; TU13; FADS2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  免疫学  神经生物学  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FADS2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Members of the fatty acid desaturase (FADS) family, including FADS1, FADS2 and FADS3, regulate the desaturation of fatty acids by introducing double bonds between defined carbons of fatty acyl chains, thereby playing an essential role in the lipid metabolic pathway. Members of this family share N-terminal cytochrome b5-like domains, C-terminal multiple membrane-spanning desaturase regions and 3 histidine box motifs. FADS2 (fatty acid desaturase 2), also known as D6D, DES6, LLCDL2 or TU13, is a 444 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one cytochrome b5 heme-binding domain. Expressed in adult and fetal heart and in adult liver, brain, lung and retina, FADS2 functions as a component of a lipid metabolic pathway and catalyzes the first step in the pathway, namely the formation of unsaturated fatty acids from polyunsaturated fatty acids. Defects in the gene encoding FADS2 are the cause of cause of fatty acid delta-6-desaturase deficiency, an affliction that is characterized by skin abnormalities, corneal ulceration and growth failure. Multiple isoforms of FADS2 exist due to alternative splicing events.

Function:
FADS2 (Fatty acid desaturase 2) catalyses the biosynthesis of highly unsaturated fatty acids from precursor essential polyunsaturated fatty acids (linoleic and alpha-linoleic acid). FADS family members comprise an N-terminal cytochrome b5-like domain and a C-terminal membrane-spanning desaturase. FADS2 is repressed by dietary highly unsaturated fatty acids. Altered expression of FADS2 may be associated with obesity-associated insulin resistance. Genetic studies have linked FADS2 to IQ and attention-deficit/hyperactivity disorder (ADHD). 

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein 

Tissue Specificity:
Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic index. 

Similarity:
Belongs to the fatty acid desaturase family. 
Contains 1 cytochrome b5 heme-binding domain. 

Database links:

Entrez Gene: 9415 Human

Entrez Gene: 56473 Mouse

Entrez Gene: 83512 Rat

Omim: 606149 Human

SwissProt: Q4R749 Cynomolgus monkey

SwissProt: O95864 Human

SwissProt: Q9Z0R9 Mouse

SwissProt: Q5REA7 Orangutan

SwissProt: Q9Z122 Rat

Unigene: 502745 Human

Unigene: 38901 Mouse

Unigene: 162483 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

脂肪酸去饱和酶(FADS)家族的成员,包括FADS1、FADS2和FADS3,通过在脂肪酰基链的限定碳之间引入双键来调节脂肪酸的去饱和,从而在脂质代谢途径中起着至关重要的作用。该家族成员共享N-末端细胞色素b5样结构域,C-末端多膜跨膜去饱和酶区域和3组氨酸盒基序。FADS2(脂肪酸去饱和酶2),也称为D6D,DES6,LLCDL2或TU13,是一种444氨基酸多通道膜蛋白,定位于内质网,并含有一种细胞色素b5血红素结合结构域。FADS2在***和胎儿心脏和***肝、脑、肺和视网膜中表达,作为脂质代谢途径的一部分起作用,并催化通路中的第一步,即由多不饱和脂肪酸形成不饱和脂肪酸。FADS2基因的缺陷是脂肪酸δ-6-去饱和酶缺乏的原因,一种以皮肤异常、角膜溃疡和生长衰竭为特征的疼痛。FADS2的多个异构体由于选择性剪接事件而存在。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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