FITC标记的胆囊收缩素A受体抗体上海沪震实业有限公司

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产品名称: FITC标记的胆囊收缩素A受体抗体
英文名称: Anti-CCKAR/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/7/10 12:13:00
详细资料:  实验方法技术资料
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诚信指数:932点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
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200612
电话:
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传真:
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陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-CCKAR/FITC Conjugated antibody

FITC标记的胆囊收缩素A受体抗体

 

产品编号 bs-11514R-FITC
英文名称 Anti-CCKAR/FITC
中文名称 FITC标记的胆囊收缩素A受体抗体
别    名 CCK A; CCK A receptor; CCK AR; CCK-AR; CCKAR_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  信号转导  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CCKAR
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction. 

Function:
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 886 Human

Entrez Gene: 12425 Mouse

Entrez Gene: 24889 Rat

Omim: 118444 Human

SwissProt: P32238 Human

SwissProt: O08786 Mouse

SwissProt: P30551 Rat

Unigene: 129 Human

Unigene: 3521 Mouse

Unigene: 10184 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

胆囊收缩素(CCK)家族的肽类已被牵连在许多重要的生理事件。这些似乎是介导通过2个一般类别的受体,A(CCKAR)和B(CCKBR),基于它们的结合亲和力CCK/胃泌素家族肽。CCK通过与A类受体结合,是胆囊收缩和胰酶分泌的主要生理介质。它似乎起着减缓胃排空、Oddi括约肌松弛和胰岛素分泌增强的作用。此外,它还被认为是胰腺生长和肿瘤发生的中介物。A类受体也被描述在垂体前叶、肌间神经丛和中枢神经系统的区域,在那里它们被牵连在摄食障碍、帕金森病、精神分裂症和药物成瘾的发病机制中。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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