FITC标记的ATRNL1蛋白抗体
产品名称: FITC标记的ATRNL1蛋白抗体
英文名称: Anti-ATRNL1/FITC
产品编号: HZ-11504R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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- 所在区域 : 上海
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Rabbit Anti-ATRNL1/FITC Conjugated antibody
FITC标记的ATRNL1蛋白抗体
产品编号 | bs-11504R-FITC |
英文名称 | Anti-ATRNL1/FITC |
中文名称 | FITC标记的ATRNL1蛋白抗体 |
别 名 | ATRN1_HUMAN; ATRNL1; Attractin-like protein 1; KIAA0534. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 147kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human ATRNL1 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: ATRNL1 is a 1,379 amino acid single-pass type I membrane protein that may play a role in melanocortin signaling pathways that regulate energy homeostasis. The ATRNL1 protein contains a C-type lectin domain, a CUB domain, two EGF-like domains, six Kelch repeats, two laminin EGF-like domains and five PSI domains. ATRNL1 interacts with MC4-R in several regions known to be important in the regulation of energy homeostasis by melanocortins, such as the paraventricular nucleus of hypothalamus and the dorsal motor nucleus of the vagus. The ATRNL1 gene is conserved in dog, cow, mouse, rat, chicken, zebrafish and C. elegans, exists as two alternatively spliced isoforms and maps to human chromosome 10q25.3. Strong evidence of linkage to late-onset Alzheimer disease (LOAD) is linked to chromosome 10, which implicates a wide region and at least one disease-susceptibility locus. Function: May play a role in melanocortin signaling pathways that regulate energy homeostasis. Subunit: Interacts with MC4R Subcellular Location: Membrane; Single-pass type I membrane protein Similarity: Contains 1 C-type lectin domain. Contains 1 CUB domain. Contains 2 EGF-like domains. Contains 6 Kelch repeats. Contains 2 laminin EGF-like domains. Contains 5 PSI domains. Database links: UniProtKB/Swiss-Prot: Q5VV63.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ATRNL1是一种1379氨基酸单通道I型膜蛋白,可能在调节能量平衡的黑皮质素信号通路中发挥作用。ATRNL1蛋白含有C型凝集素结构域、CuB结构域、两个表皮生长因子样结构域、六个Kelch重复序列、两个层粘连蛋白EGF样结构域和五个PSI结构域。ATRNL1与MC4-R相互作用,在几个区域中被认为是重要的,在调节能量平衡的黑皮质素,如下丘脑室旁核和迷走神经的背侧运动核。ATRNL1基因在狗、牛、小鼠、大鼠、鸡、斑马鱼和秀丽线虫中是保守的,作为两种交替剪接的亚型存在,并被映射到人类染色体10q25.3。与迟发性阿尔茨海默病(Load)连锁的有力证据与10号染色体有关,这暗示了一个宽的区域和至少一个疾病易感性位点。