FITC标记的GDNF家族受体α3抗体 GFR α3
产品名称： FITC标记的GDNF家族受体α3抗体 GFR α3
英文名称： Anti-GFR alpha 3/FITC
产品编号： HZ-11501R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-GFR alpha 3/FITC Conjugated antibody
FITC标记的GDNF家族受体α3抗体 GFR α3
| 产品编号 | bs-11501R-FITC |
| 英文名称 | Anti-GFR alpha 3/FITC |
| 中文名称 | FITC标记的GDNF家族受体α3抗体 GFR α3 |
| 别 名 | GFRA3; GDNF family receptor alpha 3; GDNF Receptor alpha 3; GFR alpha 3; GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3; GFRA3; GFRA3_HUMAN; Glial cell line derived neurotrophic factor receptor alpha 3; GPI linked receptor. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GFR alpha 3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF Beta superfamily of growth factors. Three receptors for these factors, GFR Alpha-1 (also designated GDNFR-Alpha, RETL1 or TrnR-1), GFR Alpha-2 (also designated GDNFR-Beta, RETL2, NTNR-Alpha or TrnR-2) and GFR Alpha-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFR Alpha-1 and GFR Alpha-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR Alpha-3 is expressed only during development. Function: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. Subcellular Location: Cell membrane. Tissue Specificity: Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. Post-translational modifications: N-glycosylated. Similarity: Belongs to the GDNFR family. Database links: Entrez Gene: 2676 Human Entrez Gene: 14587 Mouse Entrez Gene: 84422 Rat Omim: 605710 Human SwissProt: O60609 Human SwissProt: O35118 Mouse Unigene: 58042 Human Unigene: 16520 Mouse Unigene: 15499 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
胶质细胞源性神经营养因子（GDNF）和相关的神经营养因子Nurn（NTN）是中枢和外周神经元的有效生存因子。GDNF是糖基化的二硫键合的同源二聚体，与生长因子的TGF-β超家族亲缘关系较远。这些因子的三个受体，GFRα1（也被命名为GDNFRα，RITL1或TrNR-1），GFRα2（也指定GDNFRβ，RITL2，NTNRα或TrNR-2）和GFRα-3已经被鉴定。受体不含跨膜结构域，并通过糖基磷酸肌醇键连接到细胞膜上。GFRα-1和GFRα-2均显示介导GDNF依赖性和NTN依赖的酪氨酸激酶RT的磷酸化和活化。GFRα-3仅在发育过程中表达。