FITC标记的钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体
英文名称: Anti-CADPS2/FITC
抗体货号: HZ-11500R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/8 11:14:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-CADPS2/FITC Conjugated antibody

FITC标记的钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体

 

产品编号 bs-11500R-FITC
英文名称 Anti-CADPS2/FITC
中文名称 FITC标记的钙依赖分泌激活蛋白2/自闭症的相关蛋白抗体
别    名 Cadps2; Calcium-dependent activator protein for secretion 2; Calcium-dependent secretion activator 2; CAPS2; CAPS2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  生长因子和***  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 148kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CADPS2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Calcium-dependent secretion activators (CAPS-1 and CAPS-2) are calcium-binding proteins that direct neurotransmitter and neuropeptide-filled vesicles to the cell membrane for secretory granule exocytosis. Both CAPS-1 and CAPS-2 are expressed primarily in the brain where they regulate the secretion of various substances. The CAPS proteins contain a PH domain that is essential for regulation of exocytosis, as well as regulation of phospholipid binding. Through their regulation of neurotrophin release from granule cells, CAPS proteins help to regulate cell fate during neuronal development. CAPS-1 is thought to regulate catecholamine release from neuronal cells, while CAPS-2 is thought to regulate release of both brain-derived neurotrophic factor and neurotrophin-3 from granule cells. Defects in the genes encoding CAPS-1 and CAPS-2 are implicated in impaired cerebral development and autism.

Function:
RelevanceCADPS2 (Ca2+-dependent activator protein for secretion) belongs to the CAPS/Cadps family and consists of two members, CAPS1 and CAPS2. Both members play an important role in secretory granule exocytosis. CADPS2 is involved in the release of two neurotrophins, brain-derived neurotrophic factor and neurotrophin-3, from parallel fibers of cerebellar granule cells. CAPS proteins are expressed predominantly in the brain. CADPS2 has been found in various brain regions including the olfactory bulb, cerebrum, hippocampal formation, thalamus, mesencephalic tegmentum, cerebellum, medulla and spinal cord. CADPS2 colocalizes with proteins related to exocytosis (VAMP and SNAP-25) and endocytosis (Dynamin I) in the cell soma and processes of the mesencephalic tegmentum and cerebellum. 

Subunit:
Homodimer (By similarity). Interacts with the dopamine receptor DRD2. 

Subcellular Location:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.

Tissue Specificity:
Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen. 

Post-translational modifications:
Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR. 

Similarity:
Contains 1 C2 domain. 
Contains 1 MHD1 (MUNC13 homology domain 1) domain. 
Contains 1 PH domain. 

Database links:
UniProtKB/Swiss-Prot: Q86UW7.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

钙依赖性分泌激活剂(CAPS-1和CAPS-2)是钙结合蛋白,其将神经递质和神经肽填充囊泡分泌到细胞膜中以分泌颗粒胞吐作用。CAPS-1和CAPS-2都主要表达在调节各种物质分泌的脑中。CAPS蛋白含有调节胞吐作用必不可少的pH域,以及调节***脂结合。通过调控颗粒细胞释放神经营养因子,CAPS蛋白有助于调节神经元发育过程中的细胞命运。CAPS-1被认为是调节儿茶酚胺从神经元细胞释放,而CAPS-2被认为是调节脑源性神经营养因子和神经营养因子-3从颗粒细胞释放。编码CAPS-1和CAPS-2的基因的缺陷与脑发育障碍和孤独症有关。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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