FITC标记的锌指蛋白321B抗体上海沪震实业有限公司

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产品名称: FITC标记的锌指蛋白321B抗体
英文名称: Anti-ZNF312B/FITC
抗体货号: HZ-11498R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/31 15:43:00
详细资料:  实验方法技术资料
浏览人数:10
诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-ZNF312B/FITC Conjugated antibody

FITC标记的锌指蛋白321B抗体

 

产品编号 bs-11498R-FITC
英文名称 Anti-ZNF312B/FITC
中文名称 FITC标记的锌指蛋白321B抗体
别    名 FEZF1; FEZ; FEZ family zinc finger 1; Fez family zinc finger protein 1; fez like; fezf1; FEZF1_HUMAN; Zinc finger protein 312 like; Zinc finger protein 312B.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  发育生物学  神经生物学  信号转导  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZNF312B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.

Function:
Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in brain. Little or no expression in other tissues. Overexpresssed specifically in gastic cancers. A 2-to 20-fold increase is found in over 50% of gastric cancer tissues.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 6 C2H2-type zinc fingers.

Database links:

Entrez Gene: 389549 Human

Entrez Gene: 73191 Mouse

SwissProt: A0PJY2 Human

SwissProt: Q0VDQ9 Mouse

Unigene: 553970 Human

Unigene: 55115 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

嗅觉感觉神经元包含嗅觉受体,嗅觉受体是G蛋白偶联受体蛋白,定位于纤毛并显示亲和力并与多种气味分子结合。嗅觉神经元从嗅上皮向嗅球发出轴突,嗅球被CNS基底层覆盖。FEZF1(Fez家族锌指蛋白1),又称前脑胚胎锌指蛋白和锌指蛋白312B,是在小鼠嗅觉上皮和下丘脑中表达的475个氨基酸核蛋白。在FEZF1缺陷小鼠中,嗅神经元轴突不到达嗅球,提示FEXF1需要嗅轴突穿过嗅球支配之前的基底层。当FEZF1转位到细胞核时,它诱导KRAS过度表达,导致ERK信号的激活。FEZF1的过度表达导致培养细胞的加速增殖和肿瘤肿块的增加。作为替代剪接事件的结果,产生了三种FEZF1异构体。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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