FITC标记的视神经视网膜相关蛋白VAX2抗体
产品名称： FITC标记的视神经视网膜相关蛋白VAX2抗体
英文名称： Anti-VAX2/FITC
产品编号： HZ-11497R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-VAX2/FITC Conjugated antibody
FITC标记的视神经视网膜相关蛋白VAX2抗体
| 产品编号 | bs-11497R-FITC |
| 英文名称 | Anti-VAX2/FITC |
| 中文名称 | FITC标记的视神经视网膜相关蛋白VAX2抗体 |
| 别 名 | DRES93; Ventral anterior homeobox 2; VAX2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞周期蛋白 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VAX2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: VAX2 is a 290 amino acid homeobox protein that plays a crucial role in development of the eye, particularly in the specification of the ventral optic vesicle and in establishment of a correct dorsoventral pattern. VAX2 acts as a transcription factor with VAX1 to cooperatively regulate retinal differentiation, neuroepithelial cell proliferation and axial polarization in the retina. Together, VAX1 and VAX2 repress transcription of Pax-6, a strong inducer of retinal development. VAX1 and VAX2 localize to the nucleus and contain one homeobox DNA-binding domain each. Function: VAX2 belongs to the EMX homeobox family and contains 1 homeobox DNA-binding domain. VAX2 gene has high sequence similarity to VAX1 gene and is almost exclusively expressed in the ventral portion of the retina during development. It may play an important role in morphogenetic processes underlying the correct development of the eye, particularly in the establishment of a correct dorsoventral pattern and may be a regulator of axial polarization in the retina. Subcellular Location: Nuclear Similarity: Belongs to the EMX homeobox family. Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: Q9UIW0.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
VAX2是一种290氨基酸同源盒蛋白，在眼部发育中起着至关重要的作用，特别是在腹侧视泡的规范和建立正确的背腹型。VAX2作为转录因子与VAX1协同调节视网膜分化，神经上皮细胞增殖和轴极化在视网膜。VAX1和VAX2共同抑制PAX-6的转录，这是视网膜发育的强诱导因子。VAX1和VAX2定位于细胞核，并含有一个同源盒DNA结合结构域。