FITC标记的神经突起生长诱导因子受体Unc5a抗体
产品名称: FITC标记的神经突起生长诱导因子受体Unc5a抗体
英文名称: Anti-Unc5a/FITC
产品编号: HZ-11495R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-Unc5a/FITC Conjugated antibody
FITC标记的神经突起生长诱导因子受体Unc5a抗体
产品编号 | bs-11495R-FITC |
英文名称 | Anti-Unc5a/FITC |
中文名称 | FITC标记的神经突起生长诱导因子受体Unc5a抗体 |
别 名 | UNC5H1; Netrin receptor UNC 5A; Netrin receptor UNC5A; Netrin receptor Unc5h1; Protein unc-5 homolog 1; Protein unc-5 homolog A; Unc 5 homolog 1; Unc 5 homolog A; Unc 5a; Unc5 a; Unc5 homolog 1; Unc5 homolog A; Unc5a; UNC5A_HUMAN; Unc5h1; FLJ16449; KIAA1976. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 神经生物学 转录调节因子 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 90kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Unc5a |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events. Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Subunit: Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC Subcellular Location: Cell membrane. The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones. Post-translational modifications: Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Similarity: Belongs to the unc-5 family. Contains 1 death domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TSP type-1 domain. Contains 1 ZU5 domain. Database links: Entrez Gene: 90249 Human Entrez Gene: 107448 Mouse Entrez Gene: 60629 Rat Omim: 607869 Human SwissProt: Q6ZN44 Human SwissProt: Q8K1S4 Mouse SwissProt: O08721 Rat Unigene: 33191 Human Unigene: 23573 Mouse Unigene: 44433 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
UNC5H家族蛋白作为NeTurin -1的跨膜受体,在轴突引导和神经细胞迁移中起着至关重要的作用。此外,当由caspase裂解以产生包含死亡结构域的细胞内片段时,UNC5H受体诱导细胞凋亡。这种活动被NeTIL-1的结合所阻断。在缺乏NeRNI-1的情况下,UNC5H受体通过抑制与锚定无关的生长和侵袭作为肿瘤抑制因子,但这些受体的突变提供了致瘤性的潜在机制。UNC5H受体在多发性肿瘤中的表达下调,包括结直肠癌、乳腺癌、卵巢癌、子宫癌、胃癌、肺癌和肾癌。UNC5H1,也称为UNC5HA(UNC-5同源物A),是UNC5H家族蛋白的成员,并定位于细胞膜。UNC5H1的三种异构体由于选择性剪接事件而存在。