FITC标记的神经突起生长诱导因子受体UNC5D抗体上海沪震实业有限公司

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产品名称: FITC标记的神经突起生长诱导因子受体UNC5D抗体
英文名称: Anti-UNC5D/FITC
抗体货号: HZ-11494R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 9:24:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-UNC5D/FITC Conjugated antibody

FITC标记的神经突起生长诱导因子受体UNC5D抗体

 

产品编号 bs-11494R-FITC
英文名称 Anti-UNC5D/FITC
中文名称 FITC标记的神经突起生长诱导因子受体UNC5D抗体
别    名 UNC5H4; UNC5D; Netrin receptor UNC5D; Netrin receptor Unc5h4; Protein unc 5 homolog D; Unc 5 homolog 4; Unc 5 homolog D (C. elegans); Unc 5 homolog D; UNC 5D; Unc5h4; FLJ16019; KIAA1777.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 102kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human UNC5H4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.

Function:
UNC5D belongs to a family of netrin 1 receptors thought to mediate the chemorepulsive effect of netrin 1 on specific axons. On ligand binding UNC5D may mediate axon repulsion of neuronal growth cones in the developing nervous system.

Subunit:
Interacts with the cytoplasmic part of DCC

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Post-translational modifications:
Phosphorylated on cytoplasmic tyrosine residues (By similarity). 
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis

Similarity:
Belongs to the unc-5 family. 
Contains 1 death domain. 
Contains 1 Ig-like (immunoglobulin-like) domain. 
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 
Contains 2 TSP type-1 domains. 
Contains 1 ZU5 domain. 

Database links:

Entrez Gene: 137970 Human

SwissProt: Q6UXZ4 Human

Unigene: 238889 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

UNC5H家族蛋白作为NeTurin -1的跨膜受体,在轴突引导和神经细胞迁移中起着至关重要的作用。此外,当由caspase裂解以产生包含死亡结构域的细胞内片段时,UNC5H受体诱导细胞凋亡。这种活动被NeTIL-1的结合所阻断。在缺乏NeRNI-1的情况下,UNC5H受体通过抑制与锚定无关的生长和侵袭作为肿瘤抑制因子,但这些受体的突变提供了致瘤性的潜在机制。UNC5H受体在多发性肿瘤中的表达下调,包括结直肠癌、乳腺癌、卵巢癌、子宫癌、胃癌、肺癌和肾癌。UNC5H4,也称为UNC5D(UNC-5同源物D),是单通道I型膜蛋白,是UNC5H NeTrin受体家族的成员。UNC5H4的两种异构体由于选择性剪接事件而存在。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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