Rabbit Anti-UNC5D/FITC Conjugated antibody
|别 名||UNC5H4; UNC5D; Netrin receptor UNC5D; Netrin receptor Unc5h4; Protein unc 5 homolog D; Unc 5 homolog 4; Unc 5 homolog D (C. elegans); Unc 5 homolog D; UNC 5D; Unc5h4; FLJ16019; KIAA1777.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||102kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human UNC5H4|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.
UNC5D belongs to a family of netrin 1 receptors thought to mediate the chemorepulsive effect of netrin 1 on specific axons. On ligand binding UNC5D may mediate axon repulsion of neuronal growth cones in the developing nervous system.
Interacts with the cytoplasmic part of DCC
Membrane; Single-pass type I membrane protein.
Phosphorylated on cytoplasmic tyrosine residues (By similarity).
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis
Belongs to the unc-5 family.
Contains 1 death domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 2 TSP type-1 domains.
Contains 1 ZU5 domain.
Entrez Gene: 137970 Human
SwissProt: Q6UXZ4 Human
Unigene: 238889 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
UNC5H家族蛋白作为NeTurin -1的跨膜受体，在轴突引导和神经细胞迁移中起着至关重要的作用。此外，当由caspase裂解以产生包含死亡结构域的细胞内片段时，UNC5H受体诱导细胞凋亡。这种活动被NeTIL-1的结合所阻断。在缺乏NeRNI-1的情况下，UNC5H受体通过抑制与锚定无关的生长和侵袭作为肿瘤抑制因子，但这些受体的突变提供了致瘤性的潜在机制。UNC5H受体在多发性肿瘤中的表达下调，包括结直肠癌、乳腺癌、卵巢癌、子宫癌、胃癌、肺癌和肾癌。UNC5H4，也称为UNC5D（UNC-5同源物D），是单通道I型膜蛋白，是UNC5H NeTrin受体家族的成员。UNC5H4的两种异构体由于选择性剪接事件而存在。