FITC标记的扭转蛋白B抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的扭转蛋白B抗体
英文名称: Anti-Torsin B/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/4 12:04:00
详细资料:  实验方法技术资料
浏览人数:19
诚信指数:820点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-Torsin B/FITC Conjugated antibody

FITC标记的扭转蛋白B抗体

 

产品编号 bs-11491R-FITC
英文名称 Anti-Torsin B/FITC
中文名称 FITC标记的扭转蛋白B抗体
别    名 DQ1; Tor1b; Torsin 1B; TOR1B; FKSG18; Torsin family 1 member B; TOR1B_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Torsin B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
TorsinB is a 336 amino acid protein that localizes to the lumen of endoplasmic reticulum and belongs to the Torsin family. Expressed in a variety of tissues with particularly high levels in adult brain, TorsinB is thought to function as a molecular chaperone that assists in the conformational folding of membrane and secreted proteins. Via its ability to regulate protein folding, TorsinB plays a key role in postnatal developmental events and is essential for proper neurological development. TorsinB contains two PKC (protein kinase C) phosphorylations sites, one ATP binding domain and several conserved cysteines and shares 69% amino acid identity with TorsinA, a related family member. Defects in the gene encoding TorsinB are associated with torsion dystonia, an autosomal dominant neurological disorder that is characterized by debilitating muscle contractions throughout the body.

Function:
Torsins are members of the AAA(+) superfamily of ATPases and are present in all multicellular organisms. Torsin B is an ER protein involved implicated in neurogenesis, neuronal migration, axon/dendrite development and synaptogenesis.

Subcellular Location:
Endoplasmic reticulum and nuclear envelope

Tissue Specificity:
Widely expressed with low levels in brain. Not detected in fetal brain.

Similarity:
Belongs to the clpA/clpB family. Torsin subfamily.

Database links:
Entrez Gene: 27348 Human
Entrez Gene: 30934 Mouse
Omim: 608050 Human
SwissProt: O14657 Human
SwissProt: Q9ER41 Mouse
Unigene: 252682 Human
Unigene: 249164 Mouse


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

TrSiNB是一种定位于内质网内腔的336氨基酸蛋白,属于Torsin家族。TrSiNB在脑中具有特别高的水平的各种组织中表达,被认为起到协助膜和分泌蛋白构象折叠的分子伴侣的作用。通过调节蛋白质折叠的能力,TorsinB在出生后的发育事件中起着关键的作用,并且对于正确的神经发育是必不可少的。TrONSB包含两个PKC(蛋白激酶C)***酸化位点,一个ATP结合域和几个保守半胱氨酸,与69%个氨基酸同一个家族成员TorsinA共享。TursNB基因的缺陷与扭转性肌张力障碍有关,它是一种常染色体显性神经系统疾病,其特征是全身衰弱的肌肉收缩。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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