FITC标记的三核苷酸重复蛋白6B抗体
产品名称： FITC标记的三核苷酸重复蛋白6B抗体
英文名称： Anti-TNRC6B/FITC
产品编号： HZ-11489R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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- 邮箱 : www.shzbio.net
Rabbit Anti-TNRC6B/FITC Conjugated antibody
FITC标记的三核苷酸重复蛋白6B抗体
| 产品编号 | bs-11489R-FITC |
| 英文名称 | Anti-TNRC6B/FITC |
| 中文名称 | FITC标记的三核苷酸重复蛋白6B抗体 |
| 别 名 | KIAA1093; TNRC 6B; Trinucleotide repeat containing 6B; Trinucleotide repeat containing gene 6B protein; TNR6B_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 194kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNRC6B (25-70aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: TNRC6B is a 1,723 amino acid protein that exists as two alternatively spliced isoforms and is thought to be involved in mRNA cleavage events. Expressed ubiquitously, TNRC6B contains one glycine/tryptophan (GW)-rich N-terminal domain, one central glutamine-rich region and one C-terminal RNA recognition motif and is encoded by a gene that maps to human chromosome 22. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias. Function: TNRC6B belongs to the GW182 family. It contains one RRM (RNA recognition motif) domain. TNRC6B plays a role in RNA mediated gene silencing by both micro RNAs (miRNAs) and short interfering RNAs (siRNAs). It is required for miRNA dependent translational repression and siRNA dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. There are three named isoforms. Subunit: Interacts with EIF2C1/AGO1, EIF2C2/AGO2, EIF2C3/AGO3 and EIF2C4/AGO4. Subcellular Location: Cytoplasm, P-body. Mammalian P-bodies are also known as GW bodies, GWBs. Similarity: Belongs to the GW182 family. Contains 1 RRM (RNA recognition motif) domain. Database links: UniProtKB/Swiss-Prot: Q9UPQ9.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
TNRC6B是一种1723个氨基酸的蛋白质，存在两个交替剪接的异构体，并被认为参与mRNA切割事件。TNRC6b普遍表达，含有一个甘氨酸/色氨酸（GW）丰富的N-末端结构域，一个中心富含谷氨酰胺的区域和一个C-末端RNA识别基序，并由映射到人类22号染色体的基因编码。映射到22号染色体的几个基因的突变参与了PelLAN McDeMID综合征、2型神经纤维瘤病、孤独症和精神分裂症的发生。此外，染色体9和5月22日之间的易位导致了费城染色体的形成和随后产生的新融合蛋白BCR-ABL，这是在几种白血病中发现的一种强有力的细胞增殖激活剂。