FITC标记的丝氨酸/苏氨酸蛋白激酶2抗体上海沪震实业有限公司

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产品名称: FITC标记的丝氨酸/苏氨酸蛋白激酶2抗体
英文名称: Anti-STK2/FITC
抗体货号: HZ-11484R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/28 13:59:00
详细资料:  实验方法技术资料
浏览人数:6
诚信指数:932点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
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传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-STK2/FITC Conjugated antibody

FITC标记的丝氨酸/苏氨酸蛋白激酶2抗体

 

产品编号 bs-11484R-FITC
英文名称 Anti-STK2/FITC
中文名称 FITC标记的丝氨酸/苏氨酸蛋白激酶2抗体
别    名 CTCL tumor antigen se20 9; LOSK; se20 9; Serine/threonine protein kinase 2; STK2; SLK; SNF1 sucrose nonfermenting like kinase; STE20 like serine/threonine-protein kinase; STE20 related kinase; STK2; SLK_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  细胞凋亡  激酶和***酸酶  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 143kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human STK2 (885-931aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
SLK is a member of the serine/threonine kinase subfamily, Ste20. This subfamily is comprised of several mammalian kinases which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase Ste20, a protein involved in relaying signals from G protein-coupled receptors to cytosolic MAP kinase cascades. Members of this subfamily include KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, GC kinase, HGK and SLK. SLK is a ubiquitously expressed protein that localizes to the cytoplasm and contains an N-terminal protein kinase domain, a central coiled-coil domain and a C-terminal ATH domain. SLK is activated through cleavage by caspase-3. SLK indirectly associates with microtubules and plays an important role in cellular stress, cell motility, cell death and cytoskeletal dynamics.

Function:
SLK is a serine/threonine protein kinase that is involved in cytoskeletal reorganization and apoptosis. SLK is a microtubule-associated protein inducing actin stress fiber disassembly, it also mediates apoptosis and it is ubiquitously expressed; highest expression is found in heart and in skeletal muscle. There are two named isoforms.

Subcellular Location:
Cytoplasmic

Tissue Specificity:
Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. 

Post-translational modifications:
Proteolytically cleaved by caspase-3. 
Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. 

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 
Contains 1 protein kinase domain. 
Contains 1 UVR domain. 

Database links:
UniProtKB/Swiss-Prot: Q9H2G2.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

SLK是丝氨酸/苏氨酸激酶亚家族的成员,STE20。该亚家族由几种哺乳动物激酶组成,其与酿酒酵母丝氨酸/苏氨酸激酶STE20呈现序列相似性,该蛋白质涉及从G蛋白偶联受体传递到胞浆MAP激酶级联的信号。该亚家族成员包括KHS、GLK、YSK1、HPK1、KRS-1、KRS-2、GC激酶、HGK和SLK。SLK是一种广泛表达的蛋白,定位于细胞质中,包含一个N-末端蛋白激酶结构域、一个中心卷曲螺旋结构域和一个C-末端ATH结构域。SLK通过Caspase-3的裂解激活。SLK间接与微管相关,在细胞应激、细胞运动、细胞死亡和细胞骨架动力学中起重要作用。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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