FITC标记的丝氨酸/苏氨酸蛋白激酶2抗体
产品名称： FITC标记的丝氨酸/苏氨酸蛋白激酶2抗体
英文名称： Anti-STK2/FITC
产品编号： HZ-11484R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
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Rabbit Anti-STK2/FITC Conjugated antibody
FITC标记的丝氨酸/苏氨酸蛋白激酶2抗体
| 产品编号 | bs-11484R-FITC |
| 英文名称 | Anti-STK2/FITC |
| 中文名称 | FITC标记的丝氨酸/苏氨酸蛋白激酶2抗体 |
| 别 名 | CTCL tumor antigen se20 9; LOSK; se20 9; Serine/threonine protein kinase 2; STK2; SLK; SNF1 sucrose nonfermenting like kinase; STE20 like serine/threonine-protein kinase; STE20 related kinase; STK2; SLK_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞凋亡 激酶和磷酸酶 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 143kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human STK2 (885-931aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SLK is a member of the serine/threonine kinase subfamily, Ste20. This subfamily is comprised of several mammalian kinases which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase Ste20, a protein involved in relaying signals from G protein-coupled receptors to cytosolic MAP kinase cascades. Members of this subfamily include KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, GC kinase, HGK and SLK. SLK is a ubiquitously expressed protein that localizes to the cytoplasm and contains an N-terminal protein kinase domain, a central coiled-coil domain and a C-terminal ATH domain. SLK is activated through cleavage by caspase-3. SLK indirectly associates with microtubules and plays an important role in cellular stress, cell motility, cell death and cytoskeletal dynamics. Function: SLK is a serine/threonine protein kinase that is involved in cytoskeletal reorganization and apoptosis. SLK is a microtubule-associated protein inducing actin stress fiber disassembly, it also mediates apoptosis and it is ubiquitously expressed; highest expression is found in heart and in skeletal muscle. There are two named isoforms. Subcellular Location: Cytoplasmic Tissue Specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. Post-translational modifications: Proteolytically cleaved by caspase-3. Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain. Contains 1 UVR domain. Database links: UniProtKB/Swiss-Prot: Q9H2G2.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SLK是丝氨酸/苏氨酸激酶亚家族的成员，STE20。该亚家族由几种哺乳动物激酶组成，其与酿酒酵母丝氨酸/苏氨酸激酶STE20呈现序列相似性，该蛋白质涉及从G蛋白偶联受体传递到胞浆MAP激酶级联的信号。该亚家族成员包括KHS、GLK、YSK1、HPK1、KRS-1、KRS-2、GC激酶、HGK和SLK。SLK是一种广泛表达的蛋白，定位于细胞质中，包含一个N-末端蛋白激酶结构域、一个中心卷曲螺旋结构域和一个C-末端ATH结构域。SLK通过Caspase-3的裂解激活。SLK间接与微管相关，在细胞应激、细胞运动、细胞死亡和细胞骨架动力学中起重要作用。