Rabbit Anti-SEMA6C/FITC Conjugated antibody
|别 名||KIAA1869; m Sema Y; m Sema Y2; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C; Sema Y antibody Semaphorin 6C [Precursor]; Semaphorin Y; SEMAY; SEM6C_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 神经生物学 细胞分化 细胞膜蛋白|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||97kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human SEMA6C (256-305aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Semaphorins are a family of cell surface and secreted proteins involved in neural development that are conserved from insects to humans. Members of this family are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin” domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. The transmembrane semaphorins are characterized by an additional 80 amino acid transmembrane domain and an 80-110 amino acid cytoplasmic domain. SEMA6C, also known as SEMA Y, is a transmembrane protein expressed in fetal brain and adult skeletal muscle. Three isoforms of this semaphorin exist due to alternative splicing: SEMA6C 1, SEMA6C 2 and SEMA6C 3. The extracellular domain of SEMA6C induces growth cone collapse of dorsal root ganglion and plays a role in generation or stability of entorhino-hippocampal synapses.
SEMA6C belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. SEMA6C shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro and may be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. SEMA6C may also be involved in the maintenance and remodeling of neuronal connections.
Membrane; Single-pass type I membrane protein.
In adult tissues, expressed only in skeletal muscle.
Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
SimaPrrin是一类细胞表面和分泌蛋白，参与昆虫的神经发育。该家族成员的长度约为750个氨基酸（包括信号序列），并由包含14-16半胱氨酸的约500个氨基酸的保守的胞外“信号素”域限定，保守序列的区块和没有明显的重复。跨膜信号素的特征是额外的80个氨基酸跨膜结构域和80-110氨基酸胞质结构域。SIMA6C，也称为SEMA-Y，是一种在胎儿脑和***骨骼肌中表达的跨膜蛋白。Sea6C 1、Sea6C 2和Sea6C 3存在选择性剪接的三种异构体。SEMA6C的胞外域诱导背根神经节的生长锥塌陷，并在内嗅海马突触的产生或稳定中起作用。