FITC标记的跨膜蛋白SEMA5B抗体
产品名称: FITC标记的跨膜蛋白SEMA5B抗体
英文名称: Anti-Semaphorin 5B/FITC
产品编号: HZ-11482R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-Semaphorin 5B/FITC Conjugated antibody
FITC标记的跨膜蛋白SEMA5B抗体
产品编号 | bs-11482R-FITC |
英文名称 | Anti-Semaphorin 5B/FITC |
中文名称 | FITC标记的跨膜蛋白SEMA5B抗体 |
别 名 | SEM5B_HUMAN; SEMA5B; SEMAG; Semaphorin-5B; Semaphorin 5B; Semaphorin5B; SemG. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 发育生物学 神经生物学 信号转导 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 126kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human SEMA5B/Semaphorin 5B (146-195aa) |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Semaphorins are a family of cell surface and secreted proteins that are conserved from insects to humans. Members of this family of proteins are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin” domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. Secreted and cell-bound semaphorins chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. SEMA5B (semaphorin-5B), also known as SEMAG, is a 1151 amino acid member of the semaphorin family. Localized to the membrane, SEMA5B is a single-pass type III protein that functions to convey positive axonal guidance cues and can induce calpain-mediated cleavage of calcineurin. Three isoforms exist due to alternative splicing events. Function: May act as positive axonal guidance cues. Subcellular Location: Membrane; Single-pass type III membrane protein. Similarity: Belongs to the semaphorin family. Contains 1 PSI domain. Contains 1 Sema domain. Contains 5 TSP type-1 domains. Database links: Entrez Gene: 54437 Human Omim: 609298 Human SwissProt: Q9P283 Human Unigene: 210870 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SimaPrrin是从昆虫到人类保守的细胞表面和分泌蛋白家族。这一家族蛋白质的成员长度约为750个氨基酸(包括信号序列),并由包含14-16个半胱氨酸的大约500个氨基酸的保守的胞外“信号素”域所定义,保守序列的区块和没有明显的重复。分泌和细胞结合的信号量化学吸引和排斥神经轴突的生长,引导复杂的神经组织网络的发展。Sima5b(SimaPur-5b),也称SAMAG,是信号素家族的1151氨基酸成员。Sima5b是一种单程型III蛋白,其功能是传递阳性轴突导向线索,并能诱导钙调神经磷酸酶介导的钙调神经磷酸酶裂解。三种异构体由于选择性剪接事件而存在。