FITC标记的轴突导向受体蛋白3抗体上海沪震实业有限公司

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产品名称: FITC标记的轴突导向受体蛋白3抗体
英文名称: Anti-Robo3/FITC
抗体货号: HZ-11476R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: 
更新时间: 2018/8/31 13:40:00
详细资料:  实验方法技术资料
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诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Robo3/FITC Conjugated antibody

FITC标记的轴突导向受体蛋白3抗体

 

产品编号 bs-11476R-FITC
英文名称 Anti-Robo3/FITC
中文名称 FITC标记的轴突导向受体蛋白3抗体
别    名 HGPPS; HGPS; RB inhibiting gene 1; Rbig 1; Rbig1; Retinoblastoma inhibiting gene 1; Rig 1; Rig1; Robo 3; Robo3; Robo3 protein; ROBO3_HUMAN; Roundabout axon guidance receptor homolog 3; Roundabout homolog 3; Roundabout like protein 3; Roundabout, axon guidance receptor, homolog 3 (Drosophila); Roundabout-like protein 3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 146kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Robo3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

Function:
Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing.

Subcellular Location:
Membrane; Single-pass type I membrane protein

DISEASE:
Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS) [MIM:607313]. Patients show a medulla where motor and sensory projections appear uncrossed.

Similarity:
Belongs to the immunoglobulin superfamily. ROBO family. 
Contains 3 fibronectin type-III domains. 
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Database links:

Entrez Gene: 489307 Dog

Entrez Gene: 100072287 Horse

Entrez Gene: 64221 Human

Entrez Gene: 19649 Mouse

Entrez Gene: 30770 Zebrafish

Omim: 608630 Human

SwissProt: Q96MS0 Human

SwissProt: Q9Z2I4 Mouse

Unigene: 435621 Human

Unigene: 212826 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

该基因是环状突起(ROBO)基因家族的成员,其控制突起生长、生长锥引导和轴突束状。Rabo蛋白是免疫球蛋白跨膜受体超家族的一个亚家族。狭缝蛋白1-3是一种分泌性化学感受器家族,是RABO蛋白的配体,SLIT/RABO相互作用除了调节神经发生外,还调节肌肉生成、白细胞迁移、肾脏形态发生、血管生成和血管生成。该基因RoF3具有一个假定的胞外结构域,具有五个免疫球蛋白(Ig)样环和三个纤连蛋白(FN)III型基序,一个跨膜段,和一个胞质尾,具有三个保守的信号基序:cc0、cc2和cc3(CC为保守胞质)。与其他机器人家族成员不同,Roop3缺少基序Cc1。Roop3基因调节神经管腹中线的轴突导航。在小鼠中,Roop3的丧失导致连合轴突完全穿过脊髓和后脑中线的完全失败。突变Roop3导致水平凝视麻痹伴进行性脊柱侧凸(HGPPS);常染色体隐性遗传障碍的特征是先天性水平凝视缺失、渐进性脊柱侧凸、髓质和体感轴突横跨髓质中线的失败。替代转录变体已被描述,但未经实验验证。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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