FITC标记的轴突导向受体蛋白3抗体
产品名称： FITC标记的轴突导向受体蛋白3抗体
英文名称： Anti-Robo3/FITC
产品编号： HZ-11476R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-Robo3/FITC Conjugated antibody
FITC标记的轴突导向受体蛋白3抗体
| 产品编号 | bs-11476R-FITC |
| 英文名称 | Anti-Robo3/FITC |
| 中文名称 | FITC标记的轴突导向受体蛋白3抗体 |
| 别 名 | HGPPS; HGPS; RB inhibiting gene 1; Rbig 1; Rbig1; Retinoblastoma inhibiting gene 1; Rig 1; Rig1; Robo 3; Robo3; Robo3 protein; ROBO3_HUMAN; Roundabout axon guidance receptor homolog 3; Roundabout homolog 3; Roundabout like protein 3; Roundabout, axon guidance receptor, homolog 3 (Drosophila); Roundabout-like protein 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 146kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Robo3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. Function: Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing. Subcellular Location: Membrane; Single-pass type I membrane protein DISEASE: Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS) [MIM:607313]. Patients show a medulla where motor and sensory projections appear uncrossed. Similarity: Belongs to the immunoglobulin superfamily. ROBO family. Contains 3 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 489307 Dog Entrez Gene: 100072287 Horse Entrez Gene: 64221 Human Entrez Gene: 19649 Mouse Entrez Gene: 30770 Zebrafish Omim: 608630 Human SwissProt: Q96MS0 Human SwissProt: Q9Z2I4 Mouse Unigene: 435621 Human Unigene: 212826 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是环状突起（ROBO）基因家族的成员，其控制突起生长、生长锥引导和轴突束状。Rabo蛋白是免疫球蛋白跨膜受体超家族的一个亚家族。狭缝蛋白1-3是一种分泌性化学感受器家族，是RABO蛋白的配体，SLIT/RABO相互作用除了调节神经发生外，还调节肌肉生成、白细胞迁移、肾脏形态发生、血管生成和血管生成。该基因RoF3具有一个假定的胞外结构域，具有五个免疫球蛋白（Ig）样环和三个纤连蛋白（FN）III型基序，一个跨膜段，和一个胞质尾，具有三个保守的信号基序：cc0、cc2和cc3（CC为保守胞质）。与其他机器人家族成员不同，Roop3缺少基序Cc1。Roop3基因调节神经管腹中线的轴突导航。在小鼠中，Roop3的丧失导致连合轴突完全穿过脊髓和后脑中线的完全失败。突变Roop3导致水平凝视麻痹伴进行性脊柱侧凸（HGPPS）；常染色体隐性遗传障碍的特征是先天性水平凝视缺失、渐进性脊柱侧凸、髓质和体感轴突横跨髓质中线的失败。替代转录变体已被描述，但未经实验验证。