Rabbit Anti-Oligophrenin 1/FITC Conjugated antibody
|别 名||Oligophrenin1; Oligophrenin-1; OPHN1_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 神经生物学 信号转导 G蛋白信号|
|交叉反应||Human, Mouse, Rat, Dog, Cow, Horse, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||92kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from huamn Oligophrenin 1 (418-465aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Ras p21 can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (1,2). Interaction of Ras p21 with GTPase activating protein (GAP) can increase the rate of hydrolysis of Ras p21-bound GTP by as much as 1000-fold (3). In mitogenically activated and tyrosine kinase-transformed cells, Ras GAP forms a complex with a protein designated p190 (4). At its amino terminus, p190 contains sequence motifs characteristic of all known GTPases, whereas the carboxy terminus contains sequences similar to those found in the Bcr gene product, n-chimerin and Rho GAP, all of which exhibit intrinsic GAP activity (4,5). Oligophrenein-1 is an additional protein with GTPase activating activity. Oligophrenein-1 is a RhoGAP protein that stimulates GTP hydrolysis of Rho subfamily members and is involved in cell migration, morphogenesis and axon outgrowth (6).
Stimulates GTP hydrolysis of members of the Rho family. Could activates GTPase targets that are known to affect cell migration and outgrowth of axons and dendrites.
Interacts with HOMER1. Interacts with AMPA receptor complexes. Interacts with SH3GL2 (endophilin-A1)
Cell junction, synapse. Cell projection, axon. Cell projection, dendritic spine. Note=Present in both presynaptic and postsynaptic sites
Expressed in brain.
Defects in OPHN1 are the cause of mental retardation X-linked OPHN1-related (MRXSO) [MIM:300486]; formerly designated MRX60. MRXSO is a syndromic mental retardation. Patients present mental retardation associated with cerebellar hypoplasia and distinctive facial dysmorphism.
Contains 1 PH domain.
Contains 1 Rho-GAP domain.
Entrez Gene: 4983 Human
Omim: 300127 Human
SwissProt: O60890 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
Ras p21可以存在于生理静止的GDP结合状态或GTP结合信号发射状态（1，2）。ras p21与GTP酶激活蛋白（GAP）的相互作用可使ras p21结合的GTP水解率增加1000倍（3）。在有丝分裂和酪氨酸激酶转化的细胞中，Ras GAP与P190（4）蛋白形成复合物。在其氨基末端，P190包含所有已知GTPases特征的序列基序，而羧基末端包含与BCR基因产物、N-嵌合蛋白和Rho GAP中发现的序列相似的序列，所有这些都显示内在的间隙活性（4，5）。寡聚蛋白-1是一种具有GTP酶激活活性的附加蛋白。寡肽素-1是一种刺激Rho亚家族成员GTP水解的RHOGAP蛋白，参与细胞迁移、形态发生和轴突生长（6）。