Rabbit Anti-Nogo B receptor/FITC Conjugated antibody
|英文名称||Anti-Nogo B receptor/FITC|
|别 名||C6orf68; NGBR; nuclear undecaprenyl pyrophosphate synthase 1 homolog; NUS1; NGBR_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||30kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human NGBR/Nogo B receptor (167-210aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B. Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing.
Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. Able to regulate vascular remodeling and angiogenesis. Its similarity with UPP synthetase proteins suggests that it may act as a scaffold for the binding of isoprenyl lipids and/or prenylated proteins.
Interacts with DHDDS, promoting its isoprenyltransferase activity. Interacts with NPC2.
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis.
Belongs to the UPP synthase family.
Entrez Gene: 116150 Human
Entrez Gene: 52014 Mouse
Entrez Gene: 294400 Rat
Omim: 610463 Human
SwissProt: Q96E22 Human
SwissProt: Q99LJ8 Mouse
Unigene: 289008 Human
Unigene: 525826 Human
Unigene: 199964 Mouse
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
NoGo是Reticulon家族的少突胶质细胞特异性成员，是CNS白质的一个组成部分，抑制轴突生长，诱导鸡背根神经节细胞的生长锥的塌陷，并抑制3T3成纤维细胞的铺展。NOGO通过少突胶质细胞表达，但不由雪旺细胞表达，主要与内质网相关联。NOGO以三种不同的剪接形式存在，NoGo-A、-B和-C. NgBR（NoGO-B受体），又称核十一酸焦***酸合成酶1同系物，是一种293氨基酸单程I型膜蛋白，通过NTAO-B作为氨基末端的特异性受体。提示，NgBR参与了血管重构和血管生成的调控。NgBR还增强了尼曼-匹克型C2蛋白（NPC2）的稳定性。NGBR mRNA的敲除导致NPC2水平降低，这导致NPC2突变的特征：细胞内胆固醇积累增加和甾醇感测丧失。