FITC标记的轴突蛋白1β抗体
产品名称： FITC标记的轴突蛋白1β抗体
英文名称： Anti-Neurexin 1 beta/FITC
产品编号： HZ-11466R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-Neurexin 1 beta/FITC Conjugated antibody
FITC标记的轴突蛋白1β抗体
| 产品编号 | bs-11466R-FITC |
| 英文名称 | Anti-Neurexin 1 beta/FITC |
| 中文名称 | FITC标记的轴突蛋白1β抗体 |
| 别 名 | Neurexin I beta; Neurexin 1; Neurexin 1 beta; Neurexin I beta; NRXN1; NRX1B_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞粘附分子 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neurexin 1 beta (281-330aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis Subunit: The cytoplasmic C-terminal region binds to CASK. Isoforms Beta 4b bind neuroligins NLGN1, NLGN2 and NLGN3, alpha-dystroglycan and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 Subcellular Location: Membrane; Single pass type I membrane protein Post-translational modifications: Highly O-glycosylated and minor N-glycosylated Similarity: Belongs to the neurexin family. Contains 1 laminin G-like domain. Database links: UniProtKB/Swiss-Prot: P58400.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Nexxin在脊椎动物神经系统中起到细胞粘附分子和受体的作用。两个NeRuxin基因是人类已知的最大的（NRXN1和NRXN3）。通过使用替代启动子，剪接位点和外显子，数百或数千个不同的mRNA的预测已经作出。大多数转录物使用上游启动子和编码α-奈鲁辛异构体；从下游启动子产生更少的转录物并编码β-纽脲素异构体。α-Nexxin含有表皮生长因子样（EGF样）序列和laminin G结构域，它们与Nexx亲蛋白相互作用。β-Nexxin缺乏EGF样序列，且含有较少的层粘连蛋白G结构域。