FITC标记的内皮细胞分化G蛋白偶联受体8抗体
产品名称： FITC标记的内皮细胞分化G蛋白偶联受体8抗体
英文名称： Anti-EDG8/FITC
产品编号： HZ-11457R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-EDG8/FITC Conjugated antibody
FITC标记的内皮细胞分化G蛋白偶联受体8抗体
| 产品编号 | bs-11457R-FITC |
| 英文名称 | Anti-EDG8/FITC |
| 中文名称 | FITC标记的内皮细胞分化G蛋白偶联受体8抗体 |
| 别 名 | EDG 8; Endothelial differentiation G protein coupled receptor 8; Endothelial differentiation G-protein-coupled receptor 8; Endothelial Differentiation Gene 8; Endothelial differentiation sphingolipid G protein coupled receptor 8; S1P receptor 5; S1P receptor Edg 8; S1P receptor Edg-8; S1P receptor Edg8; S1P5; S1PR5; S1PR5_HUMAN; Sphingosine 1 Phosphate Receptor 5; Sphingosine 1 phosphate receptor Edg 8; Sphingosine 1 phosphate receptor Edg8; Sphingosine 1-phosphate receptor 5; Sphingosine 1-phosphate receptor Edg-8; SPPR 1; SPPR 2; SPPR1; SPPR2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 神经生物学 信号转导 G蛋白偶联受体 表观遗传学 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EDG8 (1-200aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through Gi/o proteins, which activate growth related pathways. Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. Subcellular Location: Cell membrane; Multi-pass membrane protein Tissue Specificity: Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 53637 Human Entrez Gene: 94226 Mouse Entrez Gene: 100141401 Pig Entrez Gene: 60399 Rat Omim: 605146 Human SwissProt: Q9H228 Human SwissProt: Q91X56 Mouse SwissProt: Q684M3 Pig SwissProt: Q9JKM5 Rat Unigene: 501561 Human Unigene: 190619 Mouse Unigene: 45601 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
EG（内皮分化基因）家族的G蛋白偶联受体由八个家族成员组成，它们结合溶血磷脂（LPL）调节剂，包括鞘氨醇-1-磷酸（SPP）和溶血磷脂酸（LPA）。EDG-1、EDG-3、EDG-5（也被命名为H218和AGR16）和EDG-8结合的SPP具有高亲和力。EDG-6是一种低亲和力的受体。LPA优先结合EDG-2、EDG-4和EDG-7。EDG受体与多个G蛋白偶联，通过RAS、MAP激酶、罗镇、磷脂酶C或其他酪氨酸激酶信号，从而导致细胞的存活、生长、迁移和分化。EG-1通过GI蛋白信号激活AKT，并在胶质瘤细胞中表达。EDG-2在脑中表达，尤其是在白质束区，而EDG-3在心血管组织和小脑中表达。EDG-4在白细胞和脑中高表达，EDG-5具有广泛的组织分布，包括心血管组织和脑组织。在淋巴和造血组织和肺中表达的EDG-6通过GI/O蛋白信号，激活生长相关通路。