FITC标记的内皮细胞分化G蛋白偶联受体8抗体上海沪震实业有限公司

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产品名称: FITC标记的内皮细胞分化G蛋白偶联受体8抗体
英文名称: Anti-EDG8/FITC
抗体货号: HZ-11457R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 11:30:00
详细资料:  实验方法技术资料
浏览人数:13
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-EDG8/FITC Conjugated antibody

FITC标记的内皮细胞分化G蛋白偶联受体8抗体

 

产品编号 bs-11457R-FITC
英文名称 Anti-EDG8/FITC
中文名称 FITC标记的内皮细胞分化G蛋白偶联受体8抗体
别    名 EDG 8; Endothelial differentiation G protein coupled receptor 8; Endothelial differentiation G-protein-coupled receptor 8; Endothelial Differentiation Gene 8; Endothelial differentiation sphingolipid G protein coupled receptor 8; S1P receptor 5; S1P receptor Edg 8; S1P receptor Edg-8; S1P receptor Edg8; S1P5; S1PR5; S1PR5_HUMAN; Sphingosine 1 Phosphate Receptor 5; Sphingosine 1 phosphate receptor Edg 8; Sphingosine 1 phosphate receptor Edg8; Sphingosine 1-phosphate receptor 5; Sphingosine 1-phosphate receptor Edg-8; SPPR 1; SPPR 2; SPPR1; SPPR2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  细胞生物  神经生物学  信号转导  G蛋白偶联受体  表观遗传学  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EDG8 (1-200aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through Gi/o proteins, which activate growth related pathways.

Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Subcellular Location:
Cell membrane; Multi-pass membrane protein

Tissue Specificity:
Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:
Entrez Gene: 53637 Human
Entrez Gene: 94226 Mouse
Entrez Gene: 100141401 Pig
Entrez Gene: 60399 Rat
Omim: 605146 Human
SwissProt: Q9H228 Human
SwissProt: Q91X56 Mouse
SwissProt: Q684M3 Pig
SwissProt: Q9JKM5 Rat
Unigene: 501561 Human
Unigene: 190619 Mouse
Unigene: 45601 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

EG(内皮分化基因)家族的G蛋白偶联受体由八个家族成员组成,它们结合溶血***脂(LPL)调节剂,包括鞘氨醇-1-***酸(SPP)和溶血***脂酸(LPA)。EDG-1、EDG-3、EDG-5(也被命名为H218和AGR16)和EDG-8结合的SPP具有高亲和力。EDG-6是一种低亲和力的受体。LPA优先结合EDG-2、EDG-4和EDG-7。EDG受体与多个G蛋白偶联,通过RAS、MAP激酶、罗镇、***脂酶C或其他酪氨酸激酶信号,从而导致细胞的存活、生长、迁移和分化。EG-1通过GI蛋白信号激活AKT,并在胶质瘤细胞中表达。EDG-2在脑中表达,尤其是在白质束区,而EDG-3在心血管组织和小脑中表达。EDG-4在白细胞和脑中高表达,EDG-5具有广泛的组织分布,包括心血管组织和脑组织。在淋巴和造血组织和肺中表达的EDG-6通过GI/O蛋白信号,激活生长相关通路。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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